Serum Angptl2is An Independent Risk Factor Of Macrovascular Complications In Type2Diabetes Mellitus

Background： Elevated serum angiopoietin-like protein2(Angptl2) levels arepositively correlated with the development of type2diabetes. Some studies have shownthat Angptl2is closely correlated with inflammation, obesity, insulin resistance and eventhe occurrence of coronary heart disease (CHD).Atherosclerosis is the most commoncomplication of type2diabetes, which can lead to the cardiovascular events’ occurrence,including coronary heart disease and Ischemic or hemorrhagic cerebrovascular disease. Asone of the macrovascular complications, atherosclerosis is quite common and is the leadingcause of death in type2diabetes patients. This topic has been investigated whether serumAngptl2levels are associated with macrovascular complications in type2diabetes patients.Methods：There were110type2diabetes patients and29healthy volunteers in thiscross-sectional study. According to the carotid intima-media thickness (IMT) and thepresence of atherosclerotic plaques obtained by carotid ultrasonography, type2diabeteswill be devided into groups: carotid atherosclerosis group (n=60) and without carotidatherosclerosis group (n=50).Serum Angptl2concentrations were measured by enzymelinked immunosorbent assay.Results：The median (interquartile range) of serum Angptl2concentrations in healthycontrol group, type2diabetes without carotid atherosclerosis and type2diabetes mellitusAngptl2with carotid atherosclerosis were0.98(0.82-1.22) ng/ml,1.17(0.76-2.47) ng/ml,3.70(2.69-4.85) ng/ml respectively. The difference between three groups havestatistical significance. Among all the subjects, Spearman correlation analysis showed thatserum Angptl2levels are significantly correlated with body mass index (r=0.262, p <0.262), waist circumference (r=0.301, p <0.301), low density lipoprotein cholesterin (r=0.222, p <0.01).In type2diabetes patients, serum Angptl2was correlated with waist circumference (r=0.223, p <0.05) and body mass index (r=0.223, p <0.05). Multiplelogistic regression analysis showed that serum Angptl2(OR=2.245, p <0.01) was anindependent risk factor of carotid atherosclerosis in type2diabetes mellitus.Conclusions：Serum Angptl2levels are increased in Type2diabetes mellitus withcarotid atherosclerosis. Serum Angptl2is positively correlated with body mass index, waistcircumference, low-density lipoprotein cholesterin which are risk factors of atherosclerosis.In type2diabetes patients,Angptl2is positively correlated with weight index and waistcircumference.Angptl2is an independent risk factor of macrovascular complications intype2diabetes. It reveals Angptl2may play a positive role in progressive macrovascularcomplications in patients with type2diabetes.