Study Of The Correlation Between The Prevalence Of Depression In Patients With Type2Diabetes And A Variety Of Risk Factors

Background:Diabetes is a chronic metabolic disease，which is characterized byhigh blood sugar and can affect multiple body organs function. In recentyears30years, the prevalence of diabetes increased significantly in China,type2diabetes in which occupies a large proportion. Because of chronicprogressive characteristics of diabetes mellitus,it often cause manypsychological problems, among them with depression is most common.At the same time, depression can affect hormone levels and the nervoussystem, lead to the rise of blood sugar levels, thereby aggravatingdiabetes and affect blood glucose control. At present more attention paidto the relationship between diabetes and depression, the prevalence ofdepression in patients with type2diabetes and the correlation betweenthe various risk factors still needs further research.Objective:Type2diabetes patients with depression can aggravate diabetesdisease progresses; the purpose of this study is to research all kinds of risk factors and prevalence of depression in patients with type2diabetesmellitus.Method:Selected286patients with type2diabetes mellitus from theoutpatient department and inpatient department of endocrinology in ourhospital, Of which134males and152females, age (55.8±13.4) years,duration of (8.0±6.1) years，BMI（27.15±1.30）kg/m2. Let patients useZung self-rated depression scale for self-determination of depression, andaccording to the measurement results patients were divided into thedepression group and non-depressed group. Collected the patient’s age,gender, height，weight，disease duration, complications and other relatedinformation. At the same time, tested the fast plasma glucose (FPG),2hour post plasma glucose (PPG), hemoglobin C (HbAlc), fasting Cpeptide levels,2hour postprandial C peptide levels, liver function index,renal function index, triglyceride (TG), total cholesterol (TC), low densitylipoprotein (LDL), high density lipoprotein (HDL) and so on. All themeasurement data were showed with （x±s）and were compared with ttest. All the count data were compared with X2test.All the data wereanalyzed by statistical software SPSS19.0. P<0.05represents statisticalsignificance. Results:In patients with type2diabetes mellitus combined incidence ofdepression was28.3%. Depression group compared with thenon-depressed group, duration of depression in patients group, thenumber of chronic complications of diabetes, body mass index (BMI) andthe combined，2-hour postprandial glucose (PPG), glycated hemoglobin(HbA1c) levels, insulin resistance index (HOMA-IR) were higher thanthe non-depressed group, and the difference was statistically significant(P <0.05). Duration of depression in patients group，fasting serum levelsof C-peptide and2-hour postprandial C-peptide levels, homeostasismodel β-cell function index (HOMA-HBCI) were lower than thenon-depressed group, the difference was statistically significant (P <0.05).But in the age difference was not statistically significant (P>0.05).Fasting plasma glucose (FPG) was slightly higher, but the difference wasnot statistically significant (P>0.05).Conclusions:The enrolled patients with type2diabetes mellitus combinedincidence of depression was28.3%. The enrolled patients with type2diabetes mellitus gender, disease duration, BMI, the number of diabetescomplications, glycemic control and insulin function are risk factors fordepression.