Clinical Analysis Of Peptic Ulcers In Patients With Type2Diabetes Mellitus

Objective:Study and observe the difference between peptic ulcers in patients withtype2diabetes mellitus and non-diabetic peptic ulcers.We mainly comparefrom the following aspects:general information，clinical manifestations，Hpinfection and eradication, ulcer type, characteristic endoscopic ulcers, ulcerhealing, differences in blood glucose levels and complications of diabetesduration on impact of peptic ulcer, analyze the clinical characteristics ofdiabetic patients with peptic ulcer, peptic ulcer explore possible effects ofdiabetes, peptic ulcer treatment of diabetes mellitus provide clinicalguidance.Method:Select216patients from the First Hospital of Jilin University hospitalrevenue from January2011to December2013period and diagnosed byendoscopy peptic ulcer patients were retrospectively analyzed.According towhether patients with type2diabetes were divided into two groups: diabeticand non-diabetic groups. First, we compare between the two groups ingeneral, clinical manifestations, Hp infection and eradication rate, ulcerhealing, differences in complications arise. Secondly, we further compare ofdiabetic group duration of diabetes, glycosylated hemoglobin level is not at the same time the incidence of peptic ulcer, Hp infection, for statisticalanalysis.Results:(1) The age，gender of patient between two groups was no obviousdifference (P>0.05);(2) diabetic group in the clinical manifestationsbloating, high incidence of asymptomatic ulcers, the differences werestatistically significant (P <0.05); compared with the control group, a lowincidence of abdominal pain (P <0.05);(3) diabetic ulcers, complex ulcerincidence is higher than in the control group (P <0.05); while the diabeticgroup duodenum the incidence of ulcers was significantly lower than thecontrol group, the difference was statistically significant (P <0.05);(4)diabetic ulcer diameter>1.0cm higher proportion of group (P <0.05);(5)diabetic group and control group comparison, Hp infection was nosignificant difference (P>0.05), but positive Hp eradication rate wassignificantly lower than the control group, the difference was statisticallysignificant (P <0.05);(6) after treatment review, diabetic ulcer healing rateslower than the control group, with statistical significance (P <0.05);(7)with the extended duration of the diabetic group, Hp infection rate is rising;(8) When the HbA1c>6.5%,the ulcer healing rate is low(P <0.05)。Conclusion:1.Diabetic patients with peptic ulcer, patients are more prone to postprandialbloating, abdominal discomfort, loss of appetite, indigestion and other symptoms, but often lack the typical rhythm of ulcer disease characterizedby abdominal pain, some DM patients with ulcers often no obvioussymptoms, easily lead treatment delay.2.Patients with non-diabetic patients with peptic ulcers in diabetic patientscompared to the high incidence of gastric ulcer, and low incidence ofduodenal ulcer, gastric ulcer which to antral ulcers and stomach ulcerscommon corner.3.When diabetic patients with peptic ulcer, endoscopic ulcers often seen inlarge deep, and easy hemorrhage, increasing the difficulty of the endoscopicexamination of the treatment of risk.4.Diabetic patients with peptic ulcer compared with non-diabetic ulcer, nosignificant difference in the prevalence of H. pylori, but Hp eradication rate,Hp eradication more difficult.5.After the same treatment regimen of anti-ulcer, peptic ulcer healingdiabetic patients is poor, poor treatment than non-diabetic patients, whileHbA1c>6.5%lower rate of ulcer healing.