Comparative Study Of The Gender Differences In Stroke

Purpose: Stroke is one of the common diseases endangering human life andhealth, the incidence and prevalence of which are high all year round,and there is arising trend,It in very important to make appropriate prevention and treatmentAccording to different etiology and risk factors for stroke. Along with the deepeningof the research on cerebrovascular disease,the gender differences of stroke patientsattracted people’s attention in the incidence, prevalence, risk factors, stroke subtype,clinical manifestation, treatment and prognosis etc.. The aim of this study was tostudy sex differences in stroke patients with onset age, risk factors, the type of stroke,ischemic stroke subtypes of the disease, the risk degree by analyzing more than1000patients with acute stroke retrospectively.In addition.Our research will discuss therelationship between ischemic stroke etiology classification and different riskfactors,and then we can impement specific diagnosis,treatment and prevention.Method:In our study,we retrospectively collected202cases of patients withhemorrhagic stroke and1143cases of ischemic cerebral apoplexy patients fromDepartment of Neurology in the First Hospital of Jilin University from November2011to November2013,recording the age and risk factors, and the mortality ofpatients with ischemic stroke, the use of thrombolytic therapy, NIHSS score.So wecan analyzed their gender differences.In addition, we will classify the patients withischemic stroke with the acute stroke treatment with low molecular weightheparin(TOAST) test to Another reference for acute stroke in the treatment of lowmolecular heparin test (TOAST) classification methods of ischemic cerebralapoplexy patients group to analyze the gender differences and related risk factorsimpact on its risk.Results: In stroke patients, the average age and the peak age of onset in womenare bigger than men. In all stroke patients, the average age of patients with ischemiccerebral vascular disease are bigger than the ones with hemorrhagic cerebrovasculardisease, and the difference was statistically significant. In the common risk factors, the proportion of hypertension and diabetes mellitus in female patients is higherthan the ones of male, but the proportion of smoking history, drinking history,homocysteine, high uric acid disease in men is significantly higher than that inwomen. Compared with cerebral hemorrhage, the risk factors significantlyassociated with cerebral infarction are hyperhomocysteinemia, atrial fibrillation,diabetes, smoking, hyperlipidemia, and compared with the cerebral infarction,hypertension and age effect cerebral hemorrhage more.In the patients with hemorrhagic cerebrovascular disease, there is no genderdifference in mortality,the average age and peak age of onset. In common risk factors,the proportion of history of smoking and drinking in men was significantly higherthan women, There is no gender difference in the effects of other risk factors forhemorrhagic cerebrovascular disease.In patients with ischemic cerebrovascular, the average age and peak age ofonset in women is higher than men. In the common risk factors, the proportion of thehypertension and diabetes mellitus in women is higher than that in men, but theproportion of smoking history, drinking history, high homocysteine, hyperuricemiain male was higher than that of female. There is no gender differences in severity,mortality, and thrombolytic therapy. In the TOAST types of ischemic stroke, thepercentage of males in LAA (large artery atherosclerotic stroke) group is higher thanthat of females, the proportion of women in CE (cardiogenic embolism) andSAO(atherosclerosis stroke stroke) is higher than men, Atrial fibrillation has asignificant role in the occurrence of CE, smoking history works significantly in theoccurrence of LAA.Conclusion:(1) There are gender differences in stroke risk factors and theaverage onset age.(2) The role of the different stroke risk factors on both ischemicstroke and hemorrhagic is different.(3) The correlation between different risks andthe incidence of different subtypes of ischemic stroke is different. Therefore, in thestudy of the research of risk factors and the prevention and treatment in stroke, weshould consider the difference of risk factors in patients of different gender and the different effects on stroke subtypes of different risk factors, so it has importantreference value and guiding significance to reduce the incidence of stroke rate,mortality and disability rate when we deal with the risk factors pertinently.