Expressions Of IGF1R In Osteosarcoma Tissues And Their Clinical Significance

Objective To investigate the expression of IGF1R (insulin-like growth factor-1receptor) in osteosarcoma of extremities, analyze its correlation with clinical andhistopathological characteristics, and further discuss its role in the prognosis ofosteosarcoma.Methods Immunohistochemical stainning was performed to investigate theexpression of IGF1R in60cases of osteosarcoma which had complete follow-up datafor more than three years.Among this group of patients,there were34males,26females;with the median age of15.5(95%CI:15.73-20.93).Furthermore, its correlation withpatients’clinical manifestations，histopathological characteristics and its significance inprognosis of osteosarcoma was analyzed basing on the clinical follow-up data.Results This experiment analyzed the expression of IGF1R in60cases of IIBosteosarcoma. Compared with that in normal bone cells, IGF1R was over-expressed inosteosarcoma cytoplasm (P=0.032). The expression of this marker has no significantdifference in the Enneking clinical staging,gender,age,size and location oftumor(P>0.05). Kaplan-Meier analysis showed that the disease free survival time inIGF1R over-expression patients was shorter than that in low-expression/negative-expression patients（P=0.023）,and the overall survival time in IGF1R over-expressionpatients was also shorter than that in low-expression/negative-expression patients（P=0.034）. There was a significant difference between those who showed IGF1R-expression and those who did not show IGF1R-expression in the overall survival time.Conclusion IGF1R expression in patients with osteosarcoma tissues wassignificantly higher than the normal bone tissue adjacent to the tumor, and IGF1R is apoor prognostic factor in patients with osteosarcoma,and the IGF1R high expression inpatients was associated with disease free survival or overall survival.