The Effect Of Smoking Cessation On Basic Treatment Of Chronic Periodontitis

Objective:Smokers with chronic periodontitis were selected, and carried onperiodontal basic therapy and smoking cessation advising. Comparing theclinical indicators of PD and AL, as well as the concentration changes of IL-6and PGE2in GCF, before and after basic therapy. Smoking, which is animportant risk factor for periodontitis. The aim of this6months prospectivestudy was to assess the adjunctive effect of smoking cessation in basic therapyof subjects with chronic periodontitis.Methods:30eligible male smokers were enrolled from Stomatology Hospital ofHeBei University, from July to December2013.The age range:32-59years,mean age was44.6. The participants met the following criteria: The subjectswere systemically healthy; Daily smoking quantity was greater than or equalto10, for3consecutive years smoking history; There were at least20teethremaining in the mouth; Had not used steroids or antimicrobial drugs or hadnot accepted any periodontal therapy for at least6months. Select the test teeth:For molars or premolars; Periodontal probing depth≥5mm, attachment loss≥3mm; Different levels of absorption of alveolar bone, but less than the rootlength of2/3; The loose of teeth should not exceed Ⅱ degree; Without dentalcaries and filling body on the neck of the observed teeth.All patents informed to take part in the study, and general informationwere collected. Shot panoramic radiographs and made full-mouth periodontalexamination. According to the test results selected the subjects and tested teeth.All patients should be carried on the oral health education and smokingcessation advising. Absorbent paper points method was used to obtain GCF ofcorresponding sites on the diagnosed day. Carried supragingival scaling after sampling, a week later Florida periodontal probe system was used withfull-mouth periodontal examination and recorded test periodontal clinicalparameters PA and AL, to determine the baseline values, then carriedsubgingival scaling and root planning. Postoperative review one month afterthe last subgigival scaling. Assess the smoking status of patients, and dividedinto two groups according to smoking status. Smoking cessation group (SC),patients had completely quite smoking, or smoking status markedly improved,the average daily cigarette consumption was less than5pieces, a total of15cases; Non smoking cessation group (NC), smoking status in patients with nosignificant improvement, the average daily amount of smoking was stillgreater than10, a total of15cases. GCF samples were collected from thesame teeth the same sites. And recorded the clinical indicators again by usingthe Florida periodontal probe system. With double antibody sandwich ELISAtest method to detect the concentration of IL-6and PGE2. The experimentaldata was statistically analyzed using SPSS13.0software.Results：1At baseline, the two groups of periodontal clinical parameters PD, AL andthe IL-6, PGE2levels in GCF were no significant difference (P>0.05).2The change of periodontal clinical indexes before and after treatment2.1After treatment PD and AL of SC group compared with before treatmentwere significantly decreased, and there was a significant difference (P<0.05).2.2After treatment PD and AL of NC group compared with before treatmentwere significantly decreased, and there was a significant difference (P<0.05).2.3Comparison between the two groups, the decreased of PD was morehigher in SC group than the decreased of NC group, and there was statisticallysignificant difference(P<0.05); The decline in the value of AL was greaterthan the NC group, although there was no significant difference (P>0.05).3The change of IL-6and PGE2levels in GCF before and after treatment3.1After treatment, the concentration level of IL-6and PGE2in GCF of SCgroup were significantly decreased, and there was a significant difference(P<0.05). 3.2After treatment the concentration of IL-6and PGE2in GCF of NC groupwere significantly decreased, and there was a significant difference (P<0.05).3.3Comparison between the two groups, the concentration decreased of IL-6and PGE2was more higher in SC group than the decreased of NC group, andthere was statistically significant difference (P<0.05).Conclusion：1Periodontal basic treatment can effectively reduce the probing depth,attachment loss, the concentration of IL-6and PGE2in GCF.2After treatment, the drop value of PD an AL in SC group was greaterthan NC group, which indicated that smoking cessation can significantlyimprove and maintain the effect of periodontal basic therapy, and reduce theprobing depth and attachment loss.3After treatment, the decreased value of concentration of IL-6and PGE2in SC group was higher than NC group, which indicated that smokingcessation can reduce the concentration of IL-6and PGE2in GCF.4Smoking is an important risk factor for periodontitis, while smokingcessation is an favorable factor and important aspect for the effect ofperiodontal basic treatment.