| Objective：Previous studies have provided evidence of structural andtask-related functional changes in the brain of patients with migraine.In thecurrent study,we adopted resting-state fMRI to investigate changes in brainfunctions of interictal menstrual migraine patients during the resting state inorder to have a further understanding of the disease.Methods: Here we utilized resting-state fMRI to measure the amplitudeof low-frequency fluctuations (ALFF) in three different frequency bands(slow-5:0.01-0.027Hz;slow-4:0.027-0.073Hz;and typical band:0.01-0.08Hz)in10patients with interictal menstrual migraine and10educational,age-matched healthy controls. To explore the ALFF differences between thegroups, a second level random-effect two-sample t test was performed on theindividual normalized ALFF maps in a voxel-by-voxel manner.And ANOVAwas used to obtain the main effect of frequency band, the main effect ofgroup,and the interaction between frequency band and group on ALFF.Results:1Patients with menstrual migraine and healthy controls both exhibitedhigher ALFF value in cingulate cortex, precuneus, inferior parietal, medialprefrontal cortex,insula and so on(P<0.05Alphasim corrected).2Compared with controls,patients showed a significant increase of ALFFvalues of the left frontal lobe,and a significant decrease of ALFF values inoccipital lobe,bilateral thalamus(P<0.05Alphasim corrected).3The main effect of group showed that compared with controls,patientshad a significant increase of ALFF values of the left frontal lobe,and asignificant decrease of ALFF values in occipital lobe, bilateral thalamus andleft cerebellum.The main effect of frequency band showed that ALFF ofvalues for slow-4were higher in cingulate cortex,thalamus,precuneus,fusiformgyrus, basal ganglia,and midbrain, and lower in lingual gyrus, middle temporal gyrus, inferior frontal gyrus and ventromedial frontal gyrus,comparison to ALFF of values in slow-5. We observed significant interactionbetween frequency band and group in the left insula,visual cortex.Conclusions: A multiple of cortical and subcortical brain regions inmenstrual migraine patients were widely functionally impaired,and abnormalneural spontaneous activity was frequency dependent. |
