Clinical Research Of Shentong ZhuYu Decoction Modified For The Prevention Of Deep Vein Thrombosis After Femoral Fracture

Objective:By observing the clinical curative effect of ShenTong ZhuYu Decoction Modified for the prevention of deep vein thrombosis after femoral fracture, to accumulate the experience of traditional Chinese medicine preventing the lower limb deep vein thrombosis.Methods:According to the admission time successively, Sixty femoral fracture patients were randomly divided into Group A (control group n=30) and Group B (treatment group n=30). Group A was given low molecular heparin calcium. Group B was given low molecular heparin calcium and ShenTong ZhuYu Decoction Modified with course of12days. Intraoperative blood loss, postoperative total flow and operation mode were recorded. In admission day1,3,7,14, blood clotting function, D-dimer, double lower limbs deep vein color doppler ultrasound examination were respectively taken. Limb circumference and pain relief were measured. The data were analyzed using statistical software SPSS18.0, setting P<0.05had statistical significance.Results:1、There were six patients had thrombosis in Group A, two patients in Group B. In Group A, it was respectively found two cases, three cases, one case in admission day3,7,14five cases in femoral vein, one case in popliteal vein. In Group B, it was respectively found one case in admission day3,7, one case in femoral vein, one case in popliteal vein. The incidence of thrombosis were respectively20.00%,6.67%. The incidence of thrombosis between the two groups had statistical significance (P<0.05).2、The differences of PT, APTT, FIB and D-dimer between the groups had no statistical significance (P>0.05) in admission day3. In admission day7,14, the differences of PT, APTT, FIB and D-dimer between the groups were significant differences (P<0.05). The INR values of the two groups showed no significant difference (P>0.05).3、In admission day3,7,14, the differences of limb and the contralateral limb weeks diameter difference and pain score between the groups were statistically significant (P<0.05).4、The difference of intraoperative blood loss and postoperative total flow between the groups had no statistical significance(P>0.05).5、 During the test, the Group B patients had no symptoms of skin mucous membrane petechiae, hematemesis, hematochezia, allergic and so on. There was no obvious increased the postoperative incision errhysis. Conclusion:The ShenTong ZhuYu Decoction Modified can improve the blood coagulation state and the blood fibrinolytic activity, relieve local swelling and pain, and improve local blood circulation. It has good prevention effect for the deep vein thrombosis after femoral fracture. And preoperative application of the ShenTong ZhuYu Decoction Modified do not increase the risk of bleeding, reflecting the safty of the medication. It shows that the ShenTong ZhuYu Decoction Modified can be early applied to prevent the deep vein thrombosis after femoral fracture. The further work can study the mechanisms through animal experiments.