Analysis The Relationship Between Clinical Characteristics And Prognosis Of94Resected Pancreas Cancer Patients

Objective: Summarize the experience of surgical treatment of pancreaticcancer, and analyze the clinical and pathological factors which affecting theprognosis of resected pancreatic cancer patients.Methods: Retrospective analysis the clinical data of patients fromJanuary2008to October2013during the Fourth Hospital of Hebei MedicalUniversity, which were been Treated with Surgery. There are10clinical stagesand pathological factors such as sex, age, preoperative CA19-9value, thevalue of preoperative TBIL, tumor size, tumor location, pancreatic invasion,lymph node metastasis and postoperative chemotherapy. And follow-up bytelephone each way, to get the informations whether they had a postoperativechemotherapy, Survival or not, the time and reason of death and others. Usethe Kaplan-Meier method for univariate analysis, and the meaningful resultswill be analysised by the COX regression model with multivariate statistical.Results: The median survival time of the94patients was16.7months.The1-year、2-year、3-year and5-year survival rates were59.0%、28.5%、15%and0%, respectively. There were75censored cases（79.8%）.In the10clinical and pathological factors，TNM stage, preoperative CA19-9values,postoperative chemotherapy, lymph node metastasis, pancreatic invasion canaffect the prognosis of pancreatic cancer, they have the significantly different(P＜0.05).Among them, the clinical stage in stage Ⅰ patients with a total of34cases, stageⅡ60cases, the Proportion are36.2%and63.8%, with thetumor stage progress, the prognosis and survival was significantly reduced，the median survival time of the stageⅠ patients was28.7months, which wassignificantly higher than the14.8months which was in stageⅡpatients, thedifference was statistically significant (P=0.001); A total of52patients foundthat the presence of lymph node metastases, median survival time was15.7 months, compared with42patients without lymph node metastasis, themedian survival time of18.0months was significantly shorter (P=0.044); Inperipancreatic infiltration packet, pancreatic invasion group have55cases, theno peripancreatic invasion group have39cases, the median survival time ofno peripancreatic infiltration was24.0months which significantly longer thanthe13.7months without peripancreatic infiltration (P=0.017); the normalCA19-9levels group have26cases, with low levels of33patients, a highlevel group of35patients, the median survival time was24.5months,15.3months and10.2months, With the increase of serum CA19-9levels, patientprognosis and survival time was significantly lower (P=0.002);30.9%of thepatients underwent postoperative chemotherapy（n=29）, the median survivaltime was18.6months, higher then the patients which didn’t accept thepostoperative chemotherapy, the median survival time was15.8months(P=0.049). The multivariate analysis confirmed the results that the TNMstaging, the preoperative CA19-9values and postoperative chemotherapywere independent prognostic factors which can affect the prognosis ofresected pancreatic cancer patients (P<0.05).Conclusions: The staging of pancreas cancer, tumour marker CA19.9and Postoperative chemotherapy are the independent prognostic factors whichaffecting the prognosis with resected pancreas cancer patients.