Research On Ultrasonic Examination Multi-parameter Evaluation Of Perioperative Period Of Thyroid Nodule

Objective: The multi-parameter indicators of ultrasonic examination ofperioperative period of thyroid nodule were researched, the characteristicvariables of significant diagnosis of benign and malignant identification ofthyroid nodule were screened, the diagnosis value was evaluated, and theoptimal ultrasonic examination solution for perioperative period of thyroidnodule was discussed.Method: Conventional ultrasound, ultrasonic elastography andultrasound contrast examinations were conducted to54thyroid nodules, theimaging symptoms of each indicator were observed, and the diagnosis effectof the evaluation indicators on malignant thyroid nodules were analyze withchi-square test, logstic regressive analysis and ROC curve etc.Result:(1)There were16malignant nodules, most of them werehypoechioc, boundary is lobulated and infiltration with microcalcification.Ultrasonic elasticity imaging class mainly for IV,V.Ultrasonic imagingperformance for more low,uneven enhancement,enhanced the boundary is notclear. There were47benign nodhles, most of which were of high-levelecho,nodule boundary clear and visible without calcification or coarsecalcification.Ultrasonic elasticity imaging class mainly for I,III. Ultrasonicimaging performance for more uniform high enhance.(2)The multi-factor regression analysis showed that themicrocalcification, elasticity imaging grading and uneven ultrasound imaginghad a significant forecast effect on the diagnosis of malignant nodules.(3) ROC curve： For the8indicators of two-dimension ultrasound, the maximum microcalcification was0.869(sensitivity to the malignant diagnosiswas75%and specificity97.87%), nodule boundary0.864(sensitivity ofborder infiltration to malignant nodule was81.25%, and specificity85.11%);the solid echopattern was0.793(sensitivity of low echo to diagnosis ofmalignant nodule was68.75%, and specificity78.72%); elasticity imaginggrading was0.874(more than Grade III is the nearest diagnosis value,sensitivity to diagnosis of malignant nodule was81.25%, and specificity93.62%); ultrasound imaging enhancement degree was0.901(sensitivity oflow enhancement to diagnosis of malignant nodule was81.25%, andspecificity91.49%); enhancement evenness was0.652(sensitivity ofunevenness to diagnosis of malignant nodule was68.75%, andspecificity61.7%). Enhanced border was0.643(sensitivity of ill-definedto diagnosis of malignant nodule was56.25%, and specificity72.34%).microcalcification+border infiltration degree was0.905(sensitivity todiagnosis of malignant nodule was87.5%, and specificity85.11%).microcalcification+border infiltration+Grade was0.920(sensitivity todiagnosis of malignant nodule was87.5%, and specificity95.74%).microcalcification+border infiltration+enhancement degree was0.942(sensitivity to diagnosis of malignant nodule was81.25%, andspecificity95.74%).microcalcification+border infiltration+Grade+enhancement degree was0.918(sensitivity to diagnosis of malignant nodulewas87.5%, and specificity95.74%).(4) The lower area of curve of single diagnosis indicator to the nodulediagnosis was more than0.8, while the combined diagnosis showed that itwas more than0.9.Conclusion: There are different ultrasound imaging characteristics between malignant thyroid nodule and benign nodules, the ultrasoundimaging has certain value to diagnose the nature of thyroid nodule clinically.The ultrasound imaging combined elasticity imaging and two-dimensionultrasound have a high value to jointly diagnose the malignant thyroid nodule.