Clinical Observation Of Treating Primary Nephrotic Syndrome Of Liver And Kidney Yin Deficiency And Spleen And Kidney Deficiency Syndrome By Glucocorticoid

[Objective]:Observe the difference of Curative effect and side effect, which produced by GCS. when you use it to treat the PNS liver and kidney Yin deficiency syndrome and spleen kidney Yang deficiency syndrome. Discuss the mechanism of traditional Chinese medicine, provide a basis for improving the clinical curative effect and reducing side effects.[Method]:Select met the inclusion criteria of primary nephrotic syndrome in60patients, Based on traditional Chinese medicine syndrome classification criteria are divided into the liver and kidney, spleen and kidney yang two groups, each group of30patients, All standard course of hormone therapy, and6months of treatment for each patient.Collect the patient’s age, gender, disease duration-24-hour urinary protein, serum albumin, serum cholesterol, triglycerides and other clinical data.Clinical symptoms, laboratory parameters (24-hour urinary protein, serum albumin, serum cholesterol, triglycerides) as the observation project.Disabled during the observation and treatment drugs for kidney damage and affect the experimental drug.The total effective rate was calculated for each group efficacy, short-term efficacy rate, to observe the various syndromes of hormone sensitivity, detailed statistical incidence of side effects of various syndromes.[Results]:(1) spleen deficiency syndrome there is always more efficient than liver kidney yin (P<0.05), was statistically significant.(2) short-term effect of spleen deficiency syndrome than liver kidney yin (P<0.05), statistically significant.(3) spleen deficiency syndrome hormone sensitive than liver kidney yin (P<0.05), statistically significant.(4) spleen deficiency syndrome laboratory than those in the liver kidney yin (P<0.05), statistically significant.(5) liver kidney yin hypertension higher than spleen deficiency syndrome (P<0.05), was statistically significant;Liver kidney yin blood sugar was higher than in spleen deficiency syndrome (P<0.05), and was statistically significant;Easy to colds, epigastric pain, between the two groups (P>0.05), no statistically significant;Acne, insomnia and other side effects of group (P <0.05), a statistically significant weight in the spleen liver kidney yin deficiency syndrome.[Conclusion]:(1) spleen deficiency syndrome hormone sensitivity, short-term effect, the total effect is better than liver kidney yin (P<0.05). Statistically significant. Mechanism may be because the hormone Shun Yeung of the goods, the initial glucocorticoids can play the role of "less angry" with fire. Can improve the pathological state of patients with spleen deficiency.(2) liver kidney yin than spleen deficiency syndrome high incidence of side effects and weight (P<0.05). was statistically significant, Jiufu hormone further Haoshang the liver and kidney yin, heavier patients Yin due to pathological conditions.