Strengthening The Spleen And Invigorating The Kidney In Patients With Chronic Obstructive Pulmonary Disease In Stable Period The Influence Of The Content IL-8and TNF-α

Objective:through clinical observation, the evaluation Sijunzitang and Jinkuishenqitang treatment of chronic obstructive pulmonary disease (the type of syndrome of spleen and kidney qi deficiency)in the clinical efficacy and the level of IL-8and TNF-alpha the impact. Objectively analysis and evaluates of the value of " Strengthening the spleen and invigorating the kidney " and provide a scientific basis for the promotion and application in the treatment of patients with stable COPD.Methods:76patients met the inclusion criteria of chronic obstructive pulmonary disease in patients with stablc.two groups may be on-demand inhaled albuterol aerosol.76patients were randomly divided into trial group(38cases) and control group(38cases).The patients of trial Group take TCM decoction of Sijunzitang and Jinkuishenqiwan,the control group aceept to the placebo.the period of treatment are4weeks;to compare the result of two groups by analyzing clinical symptom and sign.the level of TNF-alpha in peripheral blood and pulmonary function (FEV1/FVC and FEV1).objective evaluation of the clinical efficacy of the Strengthening the spleen and invigorating the kidney of stable COPD.Results:Compared with the control group, melioration of the trial group,such as cough. wheezing.sputum.sputum volume.fatigue are better than the control group.And the level of IL-8and TNF-alpha was significantly lower than the control group;it also can significantly improve the patients’ lives quality score(CAT score).the above result show that the treatment group is better than the control group. No significant improvement in lung function in the two groups.Conclusion:Sijunzitang is and Jinkuishenqitang soup treatment of chronic obstructive pulmonary disease stabilization period (spleen and kidney qi deficiency).can significantly reduce the clinical symptoms of patients,to reduce the frequency of acute attacks.can also improve the patient’s exercise tolerance significantly, thereby improving the patient’s quality of life.One of the mechanisms of the treatment may be improved by reducing the level of IL-8and TNF-alpha as to decline the airway inflammation.