The Determination And Analysis Of The Level Of TSH,FT4, TT4in Serum And Urinary Iodine Of Early Pregnant Women And Childbearing Women In Changsha City

Objective:The aim is to explore the level of TSH, FT4and TT4in early pregnant women and childbearing women in Changsha, whose thyroid autoantibodies are negative. We also want to understand urine iodine in early pregnant women and childbearing women of Changsha, to explore the relationship between urinary iodine and TSH, FT4, TT41evel and thyroid autoantibodies.Methods:We collected early pregnant women (gestational age≤12weeks) and childbearing age women respectively100in communities of Changsha; collected fasting venous blood and morning urine, we determined TPOAb, TGAb, TSH, FT4and TT4with method of chemiluminescence, we determined TSH, FT4and TT4in the women whose TPOAb and TGAb are negative; we determined urinary iodine by the way of standardized arsenic cerium catalytic spectrophotometric. All subjects voluntarily completed a questionnaire, including basic information (name, age, occupation, etc.), eating habits(Iodine-containing food, iodine-containing drugs, iodine supplement, contact with iodine,etc.), menstrual and reproductive history. Results:1. The level of TSH in early pregnant women and childbearing are1.27mIU/L,2.21mIU/L respectively, the difference was statistically significant(P<0.001); The level of FT4are15.79±2.42pmol/L,15.46±1.52pmol/L respectively, the difference was not statistically significant(P>0.05); The level of TT4are134.35±34.06nmol/L,108.52±15.77nmol/L, the difference was statistically significant(P<0.001).2. The positive rate of antibodies is15%in early pregnant women, TPOAb was8%and TGAb was10%respectively; The positive rate of antibodies is13%in women of childbearing age, TPOAb was11%and TGAb was6%respectively, there was not statistically significant between two groups(P>0.05).3. The median urinary iodine in early pregnancy and childbearing are200.42μg/L,194.14μg/L, the difference was not statistically significant(P>0.05), where women in early pregnancy in the proportion of iodine deficiency, iodine sufficient, iodine than adequate and iodine excess are32.3%,34.3%,28.3%,5.1%respectively, while in childbearing women are16%,37%,26%,21%respectively, the proportion of iodine nutrition is different(P<0.05).4. The level of TSH, FT4and TT4in iodine deficiency, iodine sufficient, iodine than adequate and iodine excess were not statistically significant difference in early pregnant women and childbearing women(P>0.05).5. The median urinary iodine in early pregnant women with antibodies positive is200.42μg/L and with antibodies positive is200.49μg/L, the difference was not statistically significant(P>0.05); the median urinary iodine in childbearing women with antibodies positive is153.82μg/L and with antibodies positive is197.22μg/L, the difference was not statistically significant(P>0.05).Conclusion:In our study, the level of TSH in early pregnant women is less than childbearing age in Changsha City, the median urinary iodine is in iodine sufficient level both early pregnant women and childbearing, However, the ratio of iodine deficiency in early pregnant women was significantly higher than childbearing group, iodine nutritional status and the level of TSH, FT4TT4and antibody positive rate were not significantly associated.