The Function Of SACC、ACC-3、ALDH+and The Relationship Between ALDH1、CD133、and CD44

Tumor stem cell theory holds that tumors derive from tumor stem cells which are the results of the aggregation of nonnal stem cells.Tumor tissues consist of heterogeneity cells. There are a very small amount of tumore clls with have similar properties with normal stem cells, The ability of self-renewal and multi-lirection potential are the roots of the tumors, proliferation、metastasis and recurrcnce. Recently, the tumor stem cell is belived baving the following biologual characteristics:(1) The trmy tumor cells amory the tumor tissue have the ability of regeneration and producing het erogeneity. Beeause the tumor stem cells have the characberistics of self-renewal and differentiation. So they can renew themselves and produce new twnor stem cells, at the scine time, they can also produce doughter cells.(2) They have multiple drug resistance and radiation resistance.(3) They have the ability of micn me tastoses of mallgiant twnor early. Tumor stem cells can construct the suitable lifferentiation and multiplication envirumment by secreting signal molecules and so on. They can survive in a totally differen micn environment from the original tumour.(4) They have the signal pathways associated with tumor cells and normal stem cells.(5) They express molecular markers related to tumor cells and stem cells. Nowadays, people have been sueeessfully separated and cultured tumor stem cells from acute myeloid leukemia, multiple myeloma, breast caneer, rain tumors, non small cell cencer, melanoma, prostate cancer and bladder cancer, and other types of cancer patients. cancer with the worl, highest incidene, aceounting the first of the cancer-relate deanses of death. Most of the patients with cancer finally die from tumor reetirrenee and metastasis.