Damage Of Dopaminergic Neurons Induced By Chronic Stress In Depressive Rats

Objective:To investigate of the quality of life of hospitalized patients with hepaticcirrhosis status quo; to explore medical coping style, level of general self-efficacy andsocial support for the status quo in patients with hepatic cirrhosis, to study theinteraction to all aspects and correlation between all aspects as well as the quality of lifein hospitalized patients with hepatic cirrhosis; in order to improve seeking new waysand improve the quality of life of patients with hepatic cirrhosis, and guide clinical careand nursing and provide a theoretical basis to explore the science of nursinginterventions.Methods：Using descriptive design，and stochastic sampling method,120HepaticCirrhosis Patients were sampled from Inner Mongolia Tongliao City hospital forinfectious diseases. And patients have to understand the purpose of the study and arewilling to cooperate. The questionnaire survey of selected study released by researchersof health status (SF-36) questionnaire, medical Ways of Coping Questionnaire(MCMQ), Perceived Social Support Scale (PSSS) and general self-efficacy scale(GSES).To apply Unified guidance language, the researchers given timely explain todoubted entries and questions. The questionnaire completed independently byresearchers,to those they can not be independently fill out the questionnaire used byresearchers Answers situation to recover on the spot.120questionnaires weredistributed,119valid questionnaires, the effective rate of98%.Data were analyzed bydescriptive analysis, t-test, variance analysis, Pearson correlation analysis and multiplestepwise regression analysis using SPSS17.0、Millitab15.0statistical software.Results:1.Social demographic informed: Survey cases age ranged19-77years,mean age49±11years. Accounted for75.6percent of men, women accounted for24.4percent. Education: junior high school below47percent, high school above53percent,Households with a monthly income of500-1500yuan accounted for23.5percent, 1500-2500yuan in29.4percent,2500-3500yuan in30.3percent, More than3500accounted for16.8percent; married accounted for89.8percent, other11.2percent;frequency of hospitalization: one time in38.7percent, two time in35.3percent,accounting for36percent of the more than2times; daily living: completely take care ofthemselves in64.7percent, basic self-care accounted for31.1percent,4.2percent can nottake care of themselves; affordability of health care costs: affordability accounted for19.3percent, basic can withstand46.2percent, there are certain difficulties accountedfor24.4percent, difficulties are accounted for10.1the%; understanding of the disease:Understanding accounted for34.4percent,63.3percent do not understand.2.(1) The hospitalized patients with hepatic cirrhosis’s level of quality of life wassignificantly lower than the norm, the difference in the scores of SF-36was statisticallysignificant（P<0.05）.(2) The patients with hepatic cirrhosis in Different living skills, the difference inthe scores of the quality of life in addition to emotional functions, the other dimensionp-value less than0.01, there were significant differences among the groups. And withpatients living skills to improve, their quality of life scores also gradually increase.(3) With withstand a decline in the ability of patients with hepatic cirrhosis of themedical costs, quality of life scores showed a decreasing trend. Variance analysis, theresults of this dimension in addition to the general health status, the remainingdimension P values were less than0.05, the difference was statistically significant.(4) Hepatic Cirrhosis patients with different level of understanding of the diseaseknowledge, the quality of life of each dimension in two dimensions on the physiologicalfunction and social function difference was statistically significant (P <0.01) by analysisof variance. Patients with cirrhosis is worse, the level of understanding of the diseaseand its corresponding lower quality level.3.(1) Hepatic Cirrhosis patients compared with the national norm, Coping styles toscore are All higher than national norm, yield and evasive way are statisticallysignificant.(2) The level of perceived social support of patients with hepatic cirrhosis in themiddle level, where family support at a high level and outside the family support in themiddle level. Self-efficacy in a low level.4.(1) the Score of quality of life to hepatic Cirrhosis patients positively correlatedwith Faced coping style(r=0.225,P=0.014), and negatively correlated withavoided(r=-0.209,P<0.05) and yielded coping styles(r=-0.542,p<0.01). (2)The Score of quality of life to hepatic Cirrhosis patients positively correlatedwith "Outside family support","social support and "self-efficacy";(3)Multiple stepwise regression analysis of quality of life of patients with hepaticCirrhosis:"Self-efficacy"、"living skills "and " yielded coping styles "have significantinfluence to the QOL of the patients with hepatic Cirrhosis.Conclusions:1. The quality of life of patients with hepatic cirrhosis is generally low;2. The hepatic cirrhosis patients more take avoided and yielded negative copingstyle;3. Lower levels in patients with hepatic cirrhosis of the level of social support andself-efficacy;4. The quality of life of patients with hepatic cirrhosis correlated with the medicalcoping style, an individual’s level of social support and self-efficacy levels;5."Self-efficacy"、"living skills "and " yielded coping styles "have significantinfluence to the quality of life of patients with hepatic Cirrhosis.