Ginseng And Lotus Leaf Extract To Prevent Obesity And Lipid-lowering Effect Reducing Weight Of Experimental Research

Purpose: Through animal experiments, the active ingredients of ginseng drink lotus leafof high-fat diet induced obese rats of body fat and blood lipids level and HE stainingpathology slice, the improvement of the situation, to further reveal the mechanism of obesityby constitution and treatment effect, for clinical provide effective treatment.Method:①Obesity model is set up：Will only weight is140-180g64healthy Wistar ratswere randomly divided into8groups, male and female all four groups, each group of eightonly. The male and female are chosen as a set of as blank group (female1male and1group),forage in common; The remaining six groups of obese group (male group2,3,4and female2,3,4groups), Fed a high fat feed (provided by experimental animal center of jilin universityexperimental animals). After feeding6Zhou Zao mould successfully in obese group2malegroup and female group2as a model group,3male and3female were divided into low-dosegroup,4male and4female divided into Chinese medicine high dose group, Each group isalways free to eat into the water. After the success of the building In addition to the blankgroup, Always feeding high fat feed.6weeks after the start filling and feeding Chinesemedicine, A period of treatment was6weeks, Total feed a course of treatment. Every week tomeasure the body weight and body length, Measurement before fasting ban water6hoursevery time.②During the experiment, observing rats every day eat water conditions andphysiological conditions, Measuring weight and body length, once a week, Measurementbefore fasting ban water6hours every time (fill each feeding time at7o ’clock in themorning).③After12weeks, Based on former fasting12hours, Eyeball blood inside15minutes let stand20minutes after the centrifugal (3000RPM), Take the supernatant fluid into4℃refrigerator save, Four level measurement for measuring blood lipids.④To be put todeath in rats after caesarean section in heart, liver, spleen, kidney, fat and fat around the uterusweighing testosterone weeks; After weighing the liver and kidney in a concentration of10%formalin fixed in the fluid, For production of HE staining pathology slice.Result: Experiment after the traditional Chinese medicine high dose group of obese ratsweight and Lee ’s index decreased, Compared with model group have statistical significance.Chinese medicine high dose group of rats serum TG, TC, HDL, LDL-C-C are improved, And there is statistical significance.Conclusion:①Ginseng drink lotus leaf and Lee ’s weight gain for obese rats couldimprove the index.②Ginseng drink lotus leaf in obese rats blood lipid four good improvement.③Ginseng drink lotus leaf has improved in the liver and adipose accumulation.④Ginsengdrink lotus leaf in no side effects, can be widely used in clinical treatment.