| Objective:To explore the sedative effects of dexmedetomidine on ventilated patients vs midazolam or propofol in ICU.Methods:56ventilated patients were divided into dexmedetomidine group (group A), midazolam group (group B), propofol group(group C).Recorded the SOFA, Ramsay score and PaO2/FiO2indicators before sedation. Heart rate, blood pressure and respiration were recorded at4h,8h and12h of sedation. The infusion were ceased after12h, then the sedative degree was assessed every60min, recover time, time to achieve satisfactory sedation and the sedation level were recorded.Results:Dexmedetomidine could achieve a good sedative effect, and has no suppression for respiration(P>0.05). After infusion, the recover time is good. But it has cardiovascular adverse effects(P<0.05).Conclusion:Dexmedetomidine has some advantage to midazolam and propofol, but we still should watch its safety. |
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