| Objectives:To determine whether vimentin could be used as a marker of gastric carcinomas with more aggressive behavior in gastric carcinoma.Methods:Vimentin expression was detected in surgically resected gastric carcinoma tissue specimens from143patients by immunohistochemistry. Correlations between vimentin expression and clinicopathological factors were evaluated using X2,Kaplan-Meier method and Cox multivariate survival models.Results:Vimentin expression was significantly correlated with age, advanced stage, poorly differentiated type, venous invasion, hepatic metastasis, and recurrence (P<0.05). The result of multivariate analysis showed that vimentin expression and lymph node metastasis were independent prognostic factors.Conclusions:Vimentin expression in epithelial cells of the surgically resected gastric adenocarcinoma tissue is an independent predictor of short survival. |
