The Expression Of RAGE And HMGB1Protein In Endometrial Adenocarcinoma And Clinical Study

Objective：To investigate the expression ofRAGE and HMGB1in Endometrialadenocarcinoma, and the association of RAGE and HMGB1expression totheoccurrence, development and metastasis of endometrial adenocarcinoma.Methods：1. paraffin-embedded specimens of20cases with normal endometrium (NE)tissues and75cases with endometrial carcinoma (EAC) tissues were collected fromthe Maternal and Child Health Hospital of Jiangxi Province Department of Pathologyin March2008to February2012.Immunohistochemical SP method was used fordetecting the expression level of RAGE protein and HMGB1protein.2.Theassociation of RAGE and HMGB1expression tosurgical-pathologic stage, histologicalgrade, myometrial invasion,age, organ metastasis and other clinicopathologicalcharacteristics were analyzed by SPSS17.0software.Results：1. The expression rate of RAGE in normal endometrial tissue was20%, theexpression rate of sample in endometrial adenocarcinoma was77.33%,The rate ofRAGE protein expression in EAC was considerably higher than that in NE tissues (p<0.01); The level expression of RAGE protein was relevant with surgical-pathologicstage and pathological grade in endometrial adenocarcinoma(P<0.05),significantcorrelation inorgan metastasis(P<0.01),while the expression of RAGE hadno relationship with age (P>0.05)2.The expression rate of HMGB1in normal endometrial tissue was20%, theexpression rate of sample in endometrial adenocarcinoma was78.8%,The rate ofHMGB1protein expression in EAC was considerably higher than that in NE tissues(p <0.01); The level expression of HMGB1protein was relevant with myometrialinvasion in endometrial adenocarcinoma(P<0.05), significantcorrelation in surgical-pathologic stage and organ metastasis(P<0.01),while the expression of HMGB1hadno relationship with age and myometrial invasion (P>0.05). Conclusions:The results suggested that RAGE and HMGB1over-expression in endometrialadenocarcinoma was relevant. RAGE and HMGB1may be related to the process ofoccurrence and development of endometrial adenocarcinoma. RAGE and HMGB1may promote tumor growth and metastasis by increasing expression. RAGE andHMGB1in endometrial adenocarcinoma are positively correlated.