The Study Of Selenium And NF-kappa B In The Patients With Autoimmune Thyroid Disease

Objective:To detect serum selenium and NF-kappaB of patients with autoimmune thyroiddisease, compared with normal controls.To investigate the role of selenium andNF-kappa B in the immune and inflammatory process of autoimmune thyroid disease.Methods:Collected from June2012to January2013,120patients of the outpatient andinpatient department of the Second Affiliated Hospital of Nanchang University,respectively, in patients with Graves’ disease in40patients, the HT40patients,and40cases of normal control. In order to well distinguish the the Graves group and the HTgroup of diseases, Graves’ group in the study is selected for TPOAb and TgAbantibody titers Masculine in patients with hyperthyroidism,while HT group is thehypothyroidism. Chemiluminescence detection the thyroid hormone and thyroidhormone antibodies. The serum selenium levels were determined by Atomicfluorescence spectrometry. ELISA methods were used to detect the plasma level ofNF-kappa B.Data using SPSS17.0statistical software for analysis, P <0.05consideredstatistically significant.Results:1.Compare with normal control, the selenium levels of Graves’ disease groupand HT groups blood is lower, P <0.05;but no significant difference between AITDitself.2.The NF-kappa B levels of Graves’ disease group and HT groups blood ishigher than normal control, P <0.05;but no significant difference between AITDitself.3. The levels of Blood selenium and NF-kappa B statistical correlationcoefficient r=-0.272, P <0.05,exists negative correlation.4. The levels of blood selenium and thyrotropin statistical correlation coefficientr=0.216，P<0.05, exists negative correlation. Conclusion：Selenium levels in patients of autoimmune thyroid disease is lower than thecontrol group, while NF-κB levels higher than the control group. Both selenium andNF-κB involved in the inflammatory process of autoimmune thyroid;selenium affectthe metabolism of the thyroid.