Expression And Significance Of IL-9in Chronic Rhinosinusitis With Nasal Polyps

Objective: To detect the expression of IL-9in plasma，peripheral bloodmononuclear cells(PBMC) and tissues of nasal polyps of patients with Chronicrhinosinusitis with polyps (CRSwNP), and compared with the normal control group.To study the relation between the IL-9and the occurrence as well as developmentof CRSwNP．Method: Collecting30cases of CRSwNP patients as the case group, and30cases of alone in patients with deviation of nasal septum as the controls. The levelof IL-9expression in plasma was detected by means of enzyme-linkedimmunosorbent assay (ELISA). RT-PCR was used to detect the expression ofIL-9mRNA in PBMC, Nasal polyps and normal nasal mucosa.Result: It is of statistical importance that the level of IL-9expression in plasmaof the experimental group was higher than control one (P<0.05). From the RT-PCRresults, we found that IL-9mRNA expression in PBMC of the experimental groupwere significantly higher than that of the control one (P<0.05), and the IL-9mRNAexpression in nasal polyps increased than the normal nasal mucosa,(P<0.05).Conclusion: The increased expression of IL-9in CRSwNP may promote thesystemic and nasal immune and inflammatory response, lead to the occurrence anddevelopment of nasal and sinus mucosal inflammation. Therefore, the inhibition ofthe expression of IL-9, regulation of the human body’s immune status, and control ofthe inflammatory response, would provide novel insights into the nasal polypstreatment.