| Objective: To investigate the risk factors and coronary angiographicfindings in elderly female patients with coronary heart disease (CHD).Methods: A total of2017consecutive patients underwent Judkins ofcoronary angiography for enrolled in this study from April2003to May2012.Clinic and angiographic factors were compared with760elderlyfemale CHD patients,475elderly female non-CHD patients,97youngfemale CHD patients and685elderly male CHD patients.Results:(1)The levels of systolic blood pressure[SBP,(154.03±28.84） vs.(146.93±27.16) mmHg], fasting blood glucose[FBG,(6.49±2.38) vs.(6.09±1.69)mmol/L], hemoglobin A1c [HbA1c,(6.54±1.26) vs.(6.16±0.92)%] and uric acid [UA,(312.45±104.73) vs.(282.46±84.54)umol/L] were significantly higher while high densitylipoprotein cholesterol [HDL-C,(1.33±0.46) vs.(1.45±0.75)mmol/L]wassignificantly lower in elderly female CHD patients than in elderly femalenon-CHD patients (all P＜0.05).(2)Multiple logistic regression analysisdemonstrated that HDL-C[OR95%CI,2.454(1.462—4.121)], UA[OR95%CI,0.997(0.995—0.999)] and HbA1c[OR95%CI,0.749(0.609—0.921)] were dependently risk factors for elderly femaleCHD patients(all P＜0.05).(3)Coronary angiography indicated that thegreat majority of elderly female CHD patients got double or triple vessellesion, and had a higher proportion of PCI than that of elderly femalenon-CHD group(48.66%vs.34.02%, P＜0.05), while it had a lower ratecompared with the elderly male CHD patients(48.66%vs.55.62%, P＜0.05)（.4）the comparison of clinical risk factors between different genderin different diseased vessels array in elderly patients with coronary heartdisease. In single vessel disease group， Hb[(126.48±11.89) vs.(134.73±13.68)], UA[(307.38±112.17) vs.(334.37±100.53)], Proportionof smoking [10(2.26%)vs.132(37.60%)] was significantly lower，whileTC[(5.06±1.53) vs.(4.66±1.46)], LDL-C[(2.81±0.88) vs.(2.61±0.80)]was significantly higher in elderly female patients than in elderly malepatient(all P＜0.05).In double vessel disease group, UA[(311.34±99.54)vs.(340.88±105.08)], Proportion of smoking [3(1.60%)vs.76(44.71%)]was significantly lower, while SBP[(159.40±29.71) vs.(147.76±25.81)],TG[(2.08±1.73) vs.(1.54±1.32)]、HDL-C[(1.32±0.42)vs.(1.19±0.39)]、LDL-C[(3.12±1.27)vs.(2.59±0.90)] was significantly higher in elderlyfemale patients than in elderly male patient（all P＜0.05）.In multi-vesseldisease group， Hb[(117.72±10.92) vs.(129.56±14.97)],UA[(322.92±116.78) vs.(358.62±110.99)], Proportion of smoking [(6(4.58%)) vs.(81(49.39%))] was significantly lower， while，HbA1c[(6.90±1.60)vs.(6.49±1.06)], TC[(5.18±1.18) vs.(4.68±1.16)]was significantly higher in elderly female patients than in elderly malepatien（tall P＜0.05）（.5）ordinal ploytomous logistic regression analysisshowed that: independent risk factors of the number of diseased vessels inelderly women with coronary heart disease was associated with age (beta=0.042, P=0.010), SBP (β=0.101, P=0.036), FBG (β=0.174, P=0.030), HbA1c (β=0.115, P=0.026), HDL-C (β=-0.660, P=0.038).Conclusions: The risk factors of HDL-C, HbA1c and UA wereindependently with elderly female CHD patients. Diffuse and severelesions were more common in elderly female CHD patients thanage-matched non-CHD control group. Age, SBP, FBG, HbA1c, HDL-Care the independent risk factors for elderly women with coronary heartdisease... |
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