240Cases Neonatal Myocardial Injury Caused By High Blood Bilirubin Analysis

Objective High neonatal bilirubin concentration is a very common disease in infants, can cause multiple organ damage. This study intends to investigate neonatal myocardial injury caused by high blood bilirubin related factors.Method Collection270cases of children with high blood bilirubin data were retrospectively analyzed,in children’s hospital of chongqing medical university from sep2012to February2013.240cases of myocardial damage and complete information included in this study, as the study group. Hyperbilirubinemia30patients randomly selected from the same time period in hospital, and no myocardial damage as a control group. Single factor test and correlation analysis of the study group are according to age, cause of hyperbilirubinemia, TSB levels.Results1. The data show that the study group CM-MB, hypersensitivity TNI,TSB values are significantly higher than the control group, P<0.05, the difference was statistically significant.2.Severe hypersensitivity TnI high bilirubin group was higher than mild high cholesterol group and the control group, the severe high cholesterol group CK-MB and mild high cholesterol had group no significant difference (P>0.05). CK-MB, hypersensitivity TnI, TSB activity level of study group was significantly positive correlation (correlation coefficient is0.42,0.34, P<0.05).3.CK-MB positive rate of study group is more than95%. Early neonatal CK-MB values are higher than the late neonatal, and CK-MB activity and age was negatively correlated (correlation coefficient is0.267, P<0.05). Late neonatal of study group,the hypersensitivity TnI were significantly higher than early neonatal, hypersensitivity TnI activity and age is no significant linear correlation (correlation coefficient is0.116, P>0.05).4.Hemolysis group with CK-MB and hypersensitivity TnI values and non hemolytic group have no significant difference (P>0.05). Neonates with Rh hemolytic disease due to ABO hemolytic disease compared with children with myocardial injury TSB levels were significantly increased (P<0.05), but two hemolysis induced myocardial injury in children with CK-MB, hypersensitivity TNI activity have no significant difference (P>0.05).Conclusion1. Neonatal hyperbilirubinemia can cause myocardial injury, the Bilirubin level is more severe, the higher the activity of the cardiac markers, CK-MB, hypersensitivity TnI activity was positively correlated with the TSB.2.Days of age and CK-MB activity was negatively correlated, CK-MB activity decreased as age increased; hypersensitivity TnI activity had no significant correlation with age; Days of age and the degree of the TSB had no significant correlation.3.CK-MB and hypersensitivity TnI are early diagnosis of neonatal myocardial damage good indicators, but can not be used alone to evaluate the extent of myocardial injury activity levels of CK-MB, hypersensitivity TnI.4.Newborns hemolytic disease caused by myocardial injury is composed of elevated bilirubin levels, hemolytic anemia, immune reaction factors such as joint action. Neonatal Rh hemolytic disease and ABO hemolytic disease caused by the myocardial injury degree had no significant difference.5.Clinicians had examines system carefully when treating high blood bilirubin neonatal, and heart and important signs and related inspection, at the same time combined with appropriate day age heart colour to exceed, electrocardiogram examination related to comprehensive analysis can improve the judgment of neonatal myocardial damage.