| ObjectiveThe aim of this study is to evaluate galectin-3’s (Gal-3) diagnostic value in acute coronary syndrome (ACS) and stable angina pectoris (SA), to confirm high sensitive C reactive protein’s (Hs-CRP) diagnostic value in them, to observe the correlation of their serum levels between severity of coronary lesion and numbers of vasculopathy in coronaryartery, and to verify whether Gal-3and Hs-CRP could be useful biomarkers of coronary atherosclerotic state.Methods1. We enrolled150patients with chest pain, who were supposed to be diagnosed as CHD, angiographically documented. According to the clinical manifestation and the result of cardioangiography (CAG), the nomorl patients were enrolled in control group (50cases), the other100patients were diagnosed with CHD, including stable angina pectoris (SA group,40cases), acute coronary syndromes (ACS group,60cases); And according to the result of CAG, they included one vessel disease group (29cases), two vessel disease group (25cases), three vessel disease group (46cases) again.2. After12to24hours suffering disease, all the serum samples of patients were collected to measure the levels of serum Gal-3and Hs-CRP.3. All the cases were underwent CAG recording the situation of coronary artery lesion. Coronary lesions were caculated by Gensini method.Result1. The comparision of traditional risk factors such as age, body mass index (BMI), sex, hypertensive disease, diabetes, smoking, FPG, TG, TC, HDL-c and LDL-c, among normal group, ACS group and SA group had no obvious statistical difference (P>0.05); and it was the same among one vessel disease group, two vessel disease group, three vessel disease group and normal group.2. Comparing with normal group and SA group, the levels of serum Gal-3and Hs-CRP were higher in ACS group.3. The serum levels of Gal-3and Hs-CRP in three vessel disease group and two vessel disease group were higher than one vessel disease group; However, there was no statistical difference between three vessel disease group and two vessel disease group.4. The levels of serum Gal-3and Hs-CRP in male had no significant difference between female. It were the same to had or hadn’t diabetes, hypertension and smoking; the levels of Gal-3had direct correlation with age (r=0.201, p=0.014), but no correlation with TG, TC, LDL-c, HDL-c and BMI.While the level of Hs-CRP had no significantly correlation with them.5. The correlation of Gensini points between the levels of Gal-3and Hs-CRP:there were correlation between Gensini points with them in ACS; the result was adverse in SA.6. The serum level of Gal-3sho-wed signifcantly correlation with the level of Hs-CRP in ACS group; but they had no correlation in SA group.7. Diagnostic values of serum Gal-3and Hs-CRP for ACS:sensitivity and spe-cificity of Gal-3for the diagnosis of ACS appeared to be higher than Hs-CRP. Are-a under the curve (AUC) for Gal-3and Hs-CRP were0.881and0.851respective-ly, and there were statistical difference between their confidence intervals of AUC.Conclusion1. The levels of Gal-3and Hs-CRP were correlation with unstable plaque. They could be useful biomarker of atherosclerotic plaque, and considered as indexes to judge the unstable plaque of CHD.2. We may evaluate the numbers of vasculopathy in coronary artery making us-e of Gal-3and Hs-CRP.3. The coronary artery lesion in ACS had correlation with Gal-3and Hs-CRP, which prompted that it had correlation with the serum levels of Gal-3and Hs-CR P. So we may evaluate the severity of coronary artery lesion making use of Gal-3and Hs-CRP in ACS.4. Gal-3and Hs-CRP showed high predictive value to ACS, and made for risk delamination of CHD; and Gal-3had higher predictive value than Hs-CRP. |
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