Clincal Study On The TCM Zheng Of The Unstable Plaque In Carotial Artery In Ischemic Stroke Patients

BackgroundStroke is the first cause of death in China, and is also an important illness leading to death or disability, in the worldwild. Ischemic stroke is the main type of stroke, accounting for3/4, its high incidence, higher mortality and morbidity brought a heavy burden and great pain to the families, patients, even the whole society. An unstable plaque in carotial artery broke off is one of the main reasons for ischemic stroke.It lead to a variety of cerebrovascular events caused by hemodynamic changes and distal embolization or situ occlusion formed by an unstable plaque in carotial artery off.Object ivesAnalysis of sydromes and physical characteristics of Ischemic stroke with carotid unstable plaques. To provide a reference for cl inical prescription, and to improve the efficacy of secondary prevention ultimately.MethodsTo Jncorporat about180patients who met the diagnostic criteria and discharged from neurology department1of Guangdong Provincial Hospital between July,2011to April,2012by using a prospective cohort study. All patients were divided into two groups with the ratio of1:2:Unstable plaque Group(Group A) and Other palque Group(Group B). Two groups of populations respectively are60and120. Col lected with the four diagnostic data detai1celly, judged the Chinese Syndrome Elements by using ((Stroke Syndrome Diagnostic Criteria)) writen by Gao Yin in2012;judged the Syndrome type by using ((Ischemic strokediagnostic criteria)) wri ten by Association of Chinese Medicine in2011; judged the physical fitness by using ((TCM constitution classification and detemi nation)) writen by Wang Qi in2009.Results1. Comparison of the two groups in the baseline conditions, in addition to smoking, other factors including age, gender, height, weight, history of alcohol consumption, physical exercise, heart disease, diabetes, hypertension, hyperlipidemia, hyperuricemia, kidney disease, family history, triglycerides, cholesterol, total bilirubin, fibrinogen and so on. Statistical analysis of the above indicators showed that there was no significant difference (P>0.05) between two groups, it had the commeasurability.2. Comparison of the two groups in the phlegmy wet syndrom、 blood stasis syndrome and Yin deficiency syndrome showed that there was no significant difference (P>0.05). Comparison of the two groups in the fire syndrome showed that there was a significant difference (P<0.05), fire syndrome in group A was higher, accouting for group A’s31.7%, group B was lower, accouting for group B’10.8%, the data suggest that the fire syndrome are more prone to the formation of unstable plaque. Comparison of the two groups in the Qi deficiency syndrome showed that there was a significant difference (P<0.05), Qi deficiency syndrome in group A was lower, accouting for group A’s35.0%, group B was higher,accouting for group B’60.0%, the data suggest Qi deficiency syndrome patients are not easily formed unstable plaques. Comparison of the two groups in the wind syndrome showed that there was a significant diffrence (P<0.05), wind syndrome in group A was higher, accouting for group A’s3.3%, group B was not have this patiants. But because of the wind syndrome patients was very few, it was no clinical significance.3. Comparison of the two groups in the Fengtanzuluo syndron、Fenghuoshangrao syndrome and Yinxufengdong syndrome showed that there was no significant, difference (P>0.05). Comparison of the two groups in the Tanrefushi syndrome showed that there was a significant difference (P<0.05), Tanrefushi syndrome in group A was higher, accouting for group A’s30.0%, group B was lower, accouting for group B’6.7%, the data suggest that the fire syndrome are more prone to the formation of unstable plaque. Comparison of the two groups in the Qi deficiency tan yu syndrome showed that, there was a significant difference (P<0.05), Qi deficiency syndrome in group A was lower, accouting for group A’s30.0%, group B was higher, accout ing for group B’64.2%, the data suggest Qi deficiency tan yu syndrome patients were not easily formed unstable plaques.4. Comparison of the two groups in the single somatoplasm showed that there was no significant difference (P>0.05). Because of the sample capacity was very few, it was not acquired positive result. Comparison of the two groups in the partial somatoplasm of peaceful, yang def iciency, yin, phlegm-dampness, dampness-heat, blood stasis, qi depression and hypersensiti vity showed that there was no significant difference (P>0.05). Comparison of the two groups in the partial somatoplasm of peaceful somatoplasm showed that there was a significant difference (P<0.05),but peaceful somatoplasm was not the partial somatoplasm, so it was no clinical significance. Somatoplasm was not a unity thing, it always has diversity. In this study, one kind of somatoplasm has7patients (11.7%), diversity of somatoplasm has53patients (88.3%) in groupA. one kind of somatoplasm has16patients (13.3%), diversity of somatoplasm has104patients (86.7%) in groupB. This result showed that the most of the sample patients were multifaruous somatoplasm.Cone l us ionIt is a quantitative change to qualitative change process from formation of unstable plaques of carotid artery to the incidence of ischemic stroke. It has the relevance between formation of unstable plaques of carotid artery and Elements of traditional Chinese medicine syndrome, TCM syndrome and physical, To provide a direction for the Chinese medicine treatment,and an objective basis for ischemic stroke prevention.