The Correlation Between β-catenin、C-fos And MMP-9Expression And Clinical、Pathological Features Of Gastrointestinal Stromal Tumors

Objective:To investigate (3-catenin、C-fos and matrix metalloproteinase (MMP-9) expression in gastrointestinal stromal tumors(GISTs).To research the relationship between these proteins expression and clinical significance、pathological features.Methods:The clinical and pathological datas of GISTs patients (n=100) were collected from Xiangya Hospital from June,2007to June,2012,then retrospectively analyzed.One hundred GISTs tissues were examined by immunohistochemistry. SPSS17.0was used to analyze immunohistochemistry results and clinical datas of one hundred patients.Results:1.In100cases of gastrointestinal stromal tumors, protein positive expression rates of β-catenin, C-fos and MMP-9were81%(81/100),79%(79/100),83%(83/100) respectively.There was no statistical significance (χ2=0.812, P=0.667).2. The differences of β-catenin, C-fos and MMP-9protein positive expression rates in GISTs with different risk classifications and with/without distant metastasis were statistical significance(P<0.05). when the risk classification grading raised,protein expression were increased.3. There existed correlation with β-catenin、C-fos and MMP-9expression in GISTs.Conclusion:When the risk classification grading were improved,the protein positive expression rates of (3-catenin, C-fos, MMP-9were increased. Protein expression in distant metastasis group was significantly higher than group without distant metastasis.There existed correlation with β-catenin、C-fos and MMP-9expression in GISTs.