| Objective:①Test the levels of testosterone and prolactin of children with Tourettesyndrome (TS) and explore the role of icretion factor in TS;②Conduct evaluationanalysis of the relation between the clinical condition and behavior characteristics ofchildren with TS and the above-mentioned endocrine hormone, as well as the possiblepathological mechanism.Method: Test the levels of testosterone and prolactin of two groups, the first groupconsists of31children with TS and the second consists of30normal children. Twogroups will go through the general condition questionnaire investigation and ChildrenBehavior Checklist (CBCL) test. Yale Global Tic Severity Scale (YGTSS) will beadopted to assess the tic severity scale of children with TS. Meanwhile, investigate andevaluate the course of disease of children with TS and check if they all have AttentionDeficit Hyperactivity Disorder (ADHD) and other clinical conditions. Compare the databetween two groups through chi=square test, t test and two-sample rank-sum test, andanalyze the variations of testosterone and prolactin of the first group under differentclinical conditions through t test and two-sample rank-sum test. Analyze the index ofcorrelation of the first group by using Pearson’s correlation analysis and Spearman’scorrelation analysis.Results:①The differences of age, gender and family type between two groupshave no statistical significance (P>0.05); while the differences of nurture style, father’seducation level and mother’s education level between two groups have statisticalsignificance (P<0.05).②According to the scores of CBCL between two groups, thegroup with TS has higher scores in flinch, somatic complaints, anxiety-depression,thinking issue, attentions, aggressive behavior, internalizing behavior, externalizingbehavior and total behavior than the NC (normal control) group. The difference betweentwo groups has statistical significance (P<0.01).③According to the endocrine hormone test results of two groups, the group with TS has higher testosterone level than the NCgroup. The difference between two groups has statistical significance (P<0.05). And thegroup with TS has lower prolactin level than the NC group. The difference between twogroups has no statistical significance (P>0.05).④Divide the group with TS into smallgroups based on the tic severity scale and compare: moderately severe tic group(testosterone level) and mild tic group, moderately severe tic group (prolactin level) andmild tic group. The difference has no statistical significance (P>0.05).⑤Divide thegroup with TS into two small groups, one group has ADHD and the other group has not.The group with ADHD has higher prolactin level than the other group. The differencebetween two groups has statistical significance (P<0.05). And the difference oftestosterone level between two small groups has no statistical significance (P>0.05).⑥The analysis on the relation between the levels of testosterone and prolactin of childrenwith TS and age, clinical conditions and family factors: the testosterone level isproportional to age (rs=0.356，P<0.05), and it is proportional to the course of disease(rs=0.555，P<0.05); the rest factors have no correlation (P>0.05).⑦The analysis on therelation between the levels of testosterone and prolactin of children with TS and CBCLtest results: the testosterone and prolactin have no relation with each factor of CBCL orthe total scores (P>0.05).Conclusion:①The children with TS have higher testosterone level than normalchildren. The testosterone level changes with age and the course of disease, the older thechildren and the longer their course of disease, more evident the testosterone levelincreases.②There are no significant difference of prolactin level between childrenwith TS and normal children. But the children with TS and ADHD have higher prolactinlevel than children with only TS.③The children with TS have obvious and extensivebehavior problems. But there is no correlation between the behaviors of children withTS and the levels of testosterone and prolactin. |
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