Clinical Epidemiology Analysis Of993Patients With Colorectal Cancer

Objective To investigate the clinical epidemiological characteristics of colorectal cancer (CRC) in Dalian area of China from2007-2011, and supply epidemiological evidence for early prevention and treatment of colorectal cancer.Methods Analysis of the clinical epidemiological data of993cases of the initial treatment patients with colorectal cancer from Dalian Central Hospital in2007-2011with retrospectively reviewed, according to the age of onset, lesions, pathological type, Dukes installments, clinical manifestations, concomitant diseases, blood type distribution,treatment modality,recurrence and metastasis,tumor markers, immunohisto-chemistry indicators and other eleven aspects, analysis of its clinical and pathological characteristics.Results:1.The age of993patients with colorectal cancer is a non-normal distribution data, The youngest patient was14years old, and the oldest is93years old,with an average age of66.7years old,and a median age of69years old, and ratio of male to female is1.19:1, the age of the male and female groups was no statistical difference (P>0.05).2. The study shows that:Rectal cancer accounted for42.8%of the total, the left colon cancer accounted for22.5%, and the right colon cancer accounted for29.6%.The prevalence of right colon cancer in Females is higher than in males,and the difference was statistically significant (P<0.05).3. The pathological type of993cases with colorectal cancer, and adenocarcinoma accounted for86.7%of the total,and moderately differentiated adenocarcinoma is the most of all,accounted for39.8%.Ulcer type is the most common type in Gross specimen which accounting for83%. The difference was statistically significant (P<0.05) for the patients with Colorectal cancer from different grading of adenocarcinoma in the five years.4.Ducks B, C, D periods accounted for95.3%when patients with newly diagnosed. T3N0M0period is the most of TNM staging in postoperative patients,which accounted for26.7%.5. Bloody stools, abdominal pain, change in bowel habits are the most common clinical symptoms of colorectal,which accounted for69.3%in symptoms of treatment.6. The most common complications of patients with colorectal cancer are colorectal polyps in clinical, and gallstones, liver and kidney cysts, diabetes, hypertension, chronic appendicitis and so on are common seen in clinical.7. The distribution of ABO blood typing of patients with colorectal cancer is O> A> B> AB in this study.O-type blood accounted for34.3%, and B-type blood accounted for27.3%,The difference was statistically significant (P<0.05) for the normal people.8. The patients underwent surgical treatment accounted for82.5%,of which the most Surgical approach is radical resection of colon and Dixon of rectal.9. Hepatic metastases accounted for42.4%of all colorectal metastasis.Recurrence occurs from2months to5years, and which occurs within18months after surgery is most commonly,that accounted for76.9%.10. The rates of CEA and CA199Joint detection is more than60%,and the CEA positive rate in patients with recurrence reached72.2%.11. The expression of Topo-Ⅱ in high and moderately differentiated adenocarcinoma was significantly lower than the poorly differentiated adenocarcinoma, with the degree of adenocarcinoma differentiation decreased,the expression intensity of Topo-Ⅱ was increased.Conclusion:1. The median age of onset in Dalian is69years old for the patients with colorectal cancer.2. Rectum the is the mainly lesion sites, and the prevalence of right colon cancer in Females is higher than in males.3. The ulcer type moderately differentiated adenocarcinoma is the most common type of clinical pathology, the constituent ratio of poorly-moderately differentiated adenocarcinoma increases, and the poorly differentiated adenocarcinoma has a decreasing trend in the five years.4. Patients with colorectal cancer were usually in late stage when for treatment.5. The clinical performance of colorectal cancer is related to the lesion sites.6. The incidence of colorectal cancer has the relevant of adenomatous polyps, and gallstones or the liver of bile duct stones, chronic appendicitis, liver and renal cysts may be the risk factors for colorectal cancer.7. The rates of People with O-type blood suffering from colorectal cancer is higher than the normal level, while B-type blood is lower than normal.8. Surgical operation is still the main method for the treatment of colorectal cancer, treatment option is also an important factor to influence the prognosis of colorectal cancer.9. Liver is the most common sites of metastases, recurrence and metastasis are also the important factor to influence the prognosis.10. Combined detection of CEA and CA199is better than a single detection in the diagnosis of the diease,the positive rate of CEA can be significantly improved in recurrence and metastasis.11. The effect of chemotherapy of poorly differentiated adenocarcinoma in clinical will be better, when high and moderately differentiated adenocarcinoma more likely to become resistant.