Study On The Effection Of Cerebral Hemorrhage Rats, Which Given Minimally Invasive Hematoma Hematoma Aspiration Combined With Dexamethasone Injected Into Hematoma

Objective: To study the effect of minimally invasive aspiration combined withdexamethasone injected in the hematoma cavity on protein expression of perihematomalhypoxia-inducible factor (HIF-1a), MMP-9，TLR4, and the content of cerebral edemaand neurological function impact.Methods90SD rats were randomly divided into sham group, the cerebralhemorrhage model group (n=18), minimally invasive aspiration group (n=18) andminimally invasive combined with dexamethasone group(n=18). The last three groupswere further divided into12h,24h,72h（n=6in each group）。The control group: the ratsreceived80ml autologous arterial blood injected into the caudate nucleus. Theminimally invasive group and combined group were given minimally invasiveaspiration after injected urokinase about two hours，and injected dexamethasone1mg/kgin the combination group at the same time. Detected protein expression of Cerebralhemorrhage peri of HIF-1a,MMP-9and TLR4in each group at each time point andcontent of the brain edema. The remaining27rats were randomly divided into cerebralhemorrhage, minimally invasive aspiration group, combined groups(n=9in eachgroup)to check neurological score in each of three time points.Results:①HIF-1a, MMP-9and TLR4positive cells in the hundreds ofsub-cerebral hemorrhage group in minimally invasive combination with dexamethasonegroup decreased was more statistically significant (P <005) compared with the cerebralhemorrhage group and minimally invasive aspiration group;②The neurological scorewas decreased in treatment group compared with the cerebral hemorrhage group, thedifference was statistically significant (P <0.05) and minimally invasive in combination with dexamethasone decreased more significantly;(3) The content of cerebral edemawas decreased in minimally invasive combined with dexamethasone compared with thecerebral hemorrhage group, the difference was statistically significant (P <0.05)Conclusion: The minimally invasive aspiration combination with dexamethasoneinjected into the hematoma cavity can significantly reduce the protein expression ofHIF-1a and MMP-9and TLR4, reduce the content of cerebral edema, and promote therecovery of neurological function.