| Purpose To investigate whether the risk of gastric cancer (GC) was associated withsingle nucleotide polymorphisms (SNPs) of a gene cluster on the chromosome17q12-q21(ERBB2amplicon) containing steroidogenic acute regulatory-related lipidtransfer domain-containing protein3(STARD3), protein phosphatase1regulatorysubunit1B (PPP1R1B/DARPP32), titin-cap (TCAP), per1-like domain-containingprotein1(PERLD1/CAB2), epidermal growth factor receptor-2(ERBB2/HER2),zinc-finger protein subfamily1A3(ZNFN1A3/IKZF3) and DNA topoisomerase2-alpha (TOP2A) genes. We also aimed at exploring the relationship with STARD3expression and clinicopathological parameters in a Chinese Han population.Methods In this case-control study, we detected26SNPs of ERBB2amplicon in311gastric cancers and425cancer-free controls by Sequenom. We examined theexpression of STARD3in primary gastric cancers and adjacent noncancerous tissueusing immumohistochemical (IHC) analysis of tissue microarrays (TMA) containing243cases from311GC patients.Results We found no associations between genetic variations in the17q12-21genecluster and GC risk in the Chinese Han population. However, we demonstrated that theSTARD3rs1877031TC genotype increased the risk of gastric mucinousadenocarcinoma and signet-ring cell carcinoma compared to the CC genotype(P=0.021, OR=2.882,95%CI=1.173-7.084). IHC data showed that expression ofSTARD3significantly correlated with gender (P=0.004), alcohol drinking (P<0.001),location of primary tumor (P=0.007), histological type (P=0.005) and differentiation (P=0.023).Conclusion We concluded that the variant rs1877031of STARD3gene was related tothe histological types of GC. Hapolotype analysis implied that the haplotype ofSTARD3might have a rippling effect on the susceptibility to GC. Increased expressionof STARD3might attribute to pathogenesis of GC, suggesting STARD3might berelated to the tumorigenesis and differentiation grade of GC in the Chinese population. |
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