The Experimental Research Of Huo Xue Qu Yu Cream Against Deep Vein Thrombosis Treatment After Fracture

Purpose: This study is the use of traditional Chinese medicine ointment fortreatment of deep vein thrombosis after fracture, explore the process for itspreparation and quality standards, and Make it better play the traditional set of squareon the clinical efficacy.Method: Trial reflux extraction method to extract the active ingredients fromstasis paste By orthogonal experiment method to filter the best extraction program, Atthe same time to inspect the quality standards, that traditional Chinese medicinepreparation pubescent Holly as the standard, use the UV to determine the totalconidial content, And then control the quality of the blood circulation paste.Result:1. The research of preparations extraction process after orthogonal test andon the actual situation lead to the best extraction process is to use8times the amountof70%ethanol, Soak for0.5hours;1.5hours reflux extraction, extracted twice totally.2. The research of the plaster matrix Filter plaster matrix, more suitablesubstrate and the best formula is: petroleum resin was6%, and1%zinc oxide3. Plaster quality standards plaster total falconoid were determined using UVspectrophotometer, total falconoid linear in the range of detectable concentration,Meet the requirements of the recoveries were in the range of95%-105%, the averagecontent of total falconoid in the determination of the three batches of plaster is83.72mg/g, Results are reasonable and comply with the clinical applicationrequirements.4. Experimental research on skin irritation and allergic Huo Xue Qu Yu plasterAfter this experiment the skin irritation test,allergy test,the animal skin repeatedcontact with the test drug,the reaction of the immune system on the skin.The animalintact skin and damaged skin contact with tested drugs produce irritatingreaction,confirming its non-damaged skin no adverse stimulate.Established a goodfoundation for clinical applications Conclusion: Stasis plaster has clear effect, stable efficacy, after irritation andsensitization test proved plaster is security and available, worthy of promotion.