Basic Research For The Model And Its Application Of Human Glucose Regulation System

The regulation of human glucose metabolism system has been an important topic in theresearch of practitioners and scholars. Ever science the biological control theory been putforward, how to build the mathematical model of blood glucose system has become the topicof scholars. In recent years, with the rapid rise of systems biology, the strongly data supportbrought by the high-throughput technology, and a major breakthrough in the field ofmathematics, physics, chemistry, had lay a strong foundation for building human bloodglucose regulation model.The whole human blood glucose regulation model, glucose and insulin system, had beenestablished based on glucose metabolic physiology rule and the application of qualitativemodeling method in this paper. Then we build each sub model of glucose and insulin systemseparately and quantitatively by comprehensive utilization of metabolic controlanalysis(MCA) and flux balance analysis(FBA), based on Michaelis-Menten kinetics. Wesimulated each sub model, and change the parameters on the basis of physiology andpathology so that the model could suitable for ordinary people and type2diabetes. Wesimulated the glucose tolerance test results and normal diet effect by changing the inputs. Wealso made a comparative analysis on the simulation result of each sub model both for ordinarypeople and type2diabetes. Finally we made a simulation of type2diabetes in taking differentdrug that treat diabetes to analysis the situation of glucose and insulin metabolism bychanging the parameters reasonable.①Endogenous Glucose Production（EGP）The design of the the EGP model assumes glucose endogenous generation rate rapidinhibition of the insulin signal in the portal vein, but with the glucose in the blood directinformation on the delay information and the expected insulin, insulin related.②Glucose Rate ofAppearance（Ra）This design is based on known about the physiology of gastric emptying and intestinalabsorption law to create a non-linear model, in this model, the stomach is still divided intotwo atrioventricular, a solid form used to represent things food, one to indicate the the chyme state of things; reaction of the small intestine with an atrioventricular description.③Glucose Utilization（U）In order to describe the human body meal (or glucose injection) after body tissue glucoseutilization, including the utilization of insulin-dependent (mainly occur in the peripheraltissues of the muscle, fat) and insulin-independent utilization (mainly occur in the plasma).We assume glucose utilization model consists of two atrioventricular insulinnon-dependent utilization occurred in the first atrioventricular, and this value is fixed,indicates that the glucose is the brain and red blood cells absorb. Insulin-dependent utilizationoccurred in the atrioventricular (distant room), it relies on the non-linear behavior of glucosein the organization.④Insulin Secretion（S）Hypothesized that insulin secretion by pancreatic β-cells, and pass into the bloodcirculation through the hepatic portal vein, portal vein slew rate, changes in blood glucoselevels, glucose signaling and insulin signal delay and other factors related to the design.⑤Glucose Renal Excretion（E）When the concentration of glucose in the blood exceeds a particular threshold value, therenal excretion of excess glucose, in order to ensure that within the environment is at steadystate, it is related to the glucose concentration, is assumed to be linear.The simulation results show that the glucose regulatory system wo designed in this paperis a reliability model that consistent with the description of physiology. We could monitoringthe blood glucose metabolism of normal subjects and type2diabetes dynamically andquantitatively by using this model. It could help to study the regulation of human glucosemetabolism better. And it would have important reference value for diabetes prediction,personalized therapy and drug screening.