The Clinical Effect Of Somatostatin Combined Endoscope In Treatment Of Hemorrhage Resulted From Rupture Of Gastroesophageal Variceal In Patients With Live Cirrhosis

Objective Cirrhosis combined esophageal gastric varices rupture bleeding (EGVB) is a severe diseases of digestive department, how to hemostasis, prevent rebleeding and save the patient is one of the important issues facing clinicians. To explore the clinical effect and the risk of prognosis of octreotide combined with tissue adhesives injected by endoscope in treatment of hemorrhage resulted from rupture of gastroesophageal variceal in patients with live cirrhosis and to provide a comprehensive treatment for clinical in treating gastroesophageal variceal bleeding.Methods88cases with live cirrhosis and gastroesophageal variceal bleeding, from July2010to December2012in the Department of Gastroenterology, Infectious Diseases, liver disease of Second People’s Hospital in Lanzhou City, were randomly divided into two groups. Patients in treatment group were given octreotide and endoscope treatment. Others in control group were given octreotide.Clinical effect and adverse reactions could be proved though comparing the two groups in initial success rate of hemostasis, rebleeding, and response rate of varicose veins. Record the age, sex, cause liver cirrhosis, liver function grade, aspartate amino transferase, alanine amino transferase, albumin, globulin, prothrombin time, partial clotting enzyme live time, fibrinogen, degree of ascites and serum sodium concentration, spontaneous peritonitis, hepatic encephalopathy of all the patients. Kaplain-Meier and Log-rank test was used for univariate analysis. Then the single factor analysis was statistically significant index to analyze multiple factors into the Cox model.Results1. Clinical efficacy The experimental results indicate that the first successful hemostasis treatment group43cases, hemostatic rate was89.5%, control group within72hours of hemostatic rate was70%, the difference was statistically significant (P<0.05).9cases in treatment group (48cases bleeding, the incidence was18.8%, control group40cases rebleeding rate was40%, the difference was statistically significant (P<0.05). In the follow-up of6months, the treatment group varices treatment effective rate was52.1%, obviously better than control group,the difference was statistically significant (P<0.05).2. Multiple factor analysis showed that liver function grade, globulin, spontaneous peritonitis, hepatic encephalopathy, esophageal gastric varices correlated with survival time of patients with cirrhosis of the liver decompensation period and the difference was statistically significant (P<0.05).Conclusion Of liver cirrhosis with esophageal varices bleeding, somatostatin combined endoscopic hemostatic therapy is a fast, effective, safe and effective means.Liver function grading, globulin, spontaneous peritonitis, hepatic encephalopathy and esophageal gastric varices degree are great factors to prognosis of cirrhosis combined esophageal gastric varices rupture bleeding.