Font Size: a A A

Piece Of Rehabilitation Treatment Of Ischemic Stroke In Clinical Curative Effect Evaluation And Intervention Of The Central Nervous Cut Brain Regions Activated MMP Expression And The Relevance Of Research

Posted on:2014-09-20Degree:MasterType:Thesis
Country:ChinaCandidate:Y Z MaFull Text:PDF
GTID:2254330425458098Subject:Internal medicine of traditional Chinese medicine
Abstract/Summary:PDF Full Text Request
Objective: Study tonic kidney slices of rehabilitation treatment clinical curative effectevaluation and intervention of ischemic stroke (MCAO) rat focal cerebral ischemia in theexpression of MMP-2and MMP-9, explore rehabilitation glial scarring effects onischemic stroke. Methods: Clinical study will be incorporated into the standard recoveryof ischemic stroke,60patients with based treatment+traditional Chinese medicine (TCM)were randomly divided into treatment group (treatment group)30cases, foundationtreatment group (control group),30cases respectively for the use of corresponding drugsfor clinical treatment, a course of4weeks. Clinical efficacy of using daily life event scale(ADL) and China’s degree of cerebral apoplexy clinical neural function defect scale (CSS)to assess, using statistical methods to deal with patients of grading, draw the conclusion.Experimental research with the method of animal experiments, common healthy male SDrats were randomly divided into control group and140,140model group, Chinesemedicine group140, model group and Chinese medicine according to Tamura method is onthe right side of the proximal MCA electric coagulation technique preparation of focalcerebral ischemia model in rats, line control rats also open-brain surgery, but no condensateshut middle cerebral artery, after the success of the Chinese traditional medicine group in building6day rehabilitation was given to fill the stomach, the dose of9g/kg/d, controlgroup and model group were given the same amount of saline solution. Respectively for3,7,14,21,28,42and56days, beheaded kill rats using gelatinases spectrometry detection ofMMP-9, MMP-2, and statistical analysis. Results: Clinical studies have shown that,through the clinical treatment of60cases, benefit kidney patients with Chinese medicinerehabilitation can effectively repair the damaged neural function, improve the patients’daily life ability, and no obvious side effects. Experimental results confirmed that in modelgroup give medicine1,2,3weeks is no significant difference in the group; Chinesetraditional medicine group after treatment for2weeks and3weeks from the early stage ofthe same group have significant difference, compared with model group compared to thesame period also have significant differences.Conclusion: Tonic kidney medicinerehabilitation can significantly improve neural function recovery in patients with ischemicstroke, obviously improve the patient’s quality of life, has a good clinical adaptability. Itsmechanism of action and late ischemia increases the expression of MMP-2and MMP-9,inhibit the excessive formation of glial scar.
Keywords/Search Tags:Glial scar, MCAO rats, Rehabilitation, The experimental research, Clinical research
PDF Full Text Request
Related items