The Study Of Risk Factors And TCM Syndrome Type For Vascular Cognitive Impairment With No Dementia

Objective:Based on the patients of Vascular cognitive impairment with nodementia(VCIND) screening, analyze its influence factors and characteristics of cognitivefunction，to provide evidence of VCIND etiology research. Study the TCM syndrome atthe same time, to off the dialectical basis for the prevention and treatment of traditionalChinese medicine for VCIND.Methods: Selecting120patients from September2011to March2013by CT or MRIdiagnosis of cerebral infarction, duration of2weeks to6months in the first affiliatedhospital of Shan dong university of TCM、the second affiliated hospital of Shandonguniversity of TCM and Ji Nan city hospital of TCM as the research object.According to theaccepted diagnostic criteria and auxiliary scale, make into the criteria of the inclusion andexclusion,selecting VCIND group80cases and NoCI group40cases. Using case-controlstudy, analyze general Information, vascular risk factors and imaging data in two groups ofpatients, simultaneously to observe syndrome, to develop and adopt unified questionnaire.Input the data obtained into Excel to establish a database, and doing statistical analysiswith SPSS17.0software. According to the data type usingχ2test, t test, rank correlation,descriptive statistics in TCM syndrome types. Inspection level forα=0.05.Results: The number of college and above educational level in VCIND group waslower than NoCI group, there was statistical difference between two groups. But nostatistical difference was in age and gender. The number of drinking in VCIND group washigher than NoCI group, there was statistical difference between two groups. In terms ofsmoking, two groups of patients were no statistical difference.Basal ganglia infarction wasmore common.The incidence of three and above infarcts was more than NoCI group, there was statistical difference between two groups. Two group of patients in Vascular riskfactors had no statistical difference. The visual space and executive function, language,abstract (similarity), memory decline were common cognitive impairment of VCIND. Theclinical nerve function damage degree has no statistical difference in two group; VCIND inADL is lower than NoCI groups ADL and MMSE was negatively correlated(r=0.204, p<0.01); ADL and MoCA is also negatively correlated （r=0.368, p <0.01). Suggestpoorer cognitive function, the worse life activity level.VCIND group commonsyndrome:phlegm turbidity resistance,blood stasis resistance, qi and blood deficiency,kidney essence deficiency. The incidence of qi deficiency, kidney essence deficiency washigher than NoCI group.Conclusion: Cognitive function was associated with educational level, loweducational level was a contributing factor for VCIND. The site of infarction in basalganglia was more common in VCIND, the number of infarcts associated with cognitivefunction, multiple infarcts may be a risk factors for VCIND. Cognitive impairment inVCIND mainly reflected in the visual space cognitive and execution function, language,abstract(similarity) and memory.VCIND in daily life activities ability levelsdropped.VCIND group common syndrome:phlegm turbidity resistance, blood stasisresistance,qi and blood deficiency, kidney essence deficiency, complex syndrome. Kidneyessence deficiency, qi deficiency was the basis of the disease, Phlegm turbidity and bloodstasis was the important factor of the disease. VCIND occurrence was the result of avariety of pathological factors work together.