A Study On3.0TMRI Diffusion Tensor Imaging On The Normal Pre-elderly

Objective:1. To understand characteristics of the normal cerebralwhite matter fiber bundle structure in the brain of young adults by using3.0TMRI diffusion tensor imaging.2. Through a3.0TMRI diffusion tensor imaging study, to compare theimaging diffusion and various anisotropies of the cerebral white matter fiberbundle structure in the brains between normal young adults and the healthymiddle-aged; and to discuss DTI’s effectiveness on the pre-elderly.Materials and Methods: Sixty healthy subjects (30men and30women aged21to59with an average age of43.3years old) underwent DTI.The results indicate the characteristics of the subjects’ average diffusioncoefficient (ADC) map and fraction anisotropy (FA) map. To analyze andobtain ADC and FA values of different region(s) of interest (ROI). Toanalyze and obtain characteristics of subjects’ ADC and FA by usingstatistics.Results: On the ADC map, signals of cerebral spinal fluid andother cerebral tissues show significant differences. The cerebral spinal fluid is of a bright high signal, and its ADC value is the largest,2.94×10-3mm2/s, whose difference with other parts’ ADC value has statisticalsignificance (P <0.05). On the FA map, the cerebral white matter fiberbundle shows distinct high signal, which bears obvious difference withcerebral spinal fluid and cerebral gray matter. FA value of the splenium ofcorpus callosum is the largest, which is0.79. In terms of gender, ADC andFA value comparison of the same ROI does not show significant differences.In terms of symmetrical structure, ADC and FA value comparison of the leftand right side does not show significant differences. However, ADC and FAvalue comparison of the same ROI between young adult group (20-30yearsold) and the pre-elderly group (40-59years old) show significantdifferences.Conclusion: On the ADC map, the cerebral spinal fluid is of a brighthigh signal that bears significant difference with other cerebral tissuesignals; but is consistent with other ADC value differences. On the FA map,the cerebral white matter fiber bundle shows distinct high signal. There aredifferences among different dissection parts. FA value of the splenium ofcorpus callosum is the largest. DTI can reflect that the change of braintissue diffusion and anisotropies is closely related to age increasing. Thisfurther indicates that the fine structure and integrity of brain tissue has alsochanged. The study on ADC and FA of the pre-elderly is beneficial to studies on early aging of normal people; and attaches clinical significance toearly detection and prevention of senile brain diseases.