| Objective: To investigate the drug resistance of clinical isolates of P.aeruginosa from Jan2009to Dec2011, and provide a reference for clinicaltreatment.Methods: Disk diffusion test was used to study the antimicrobialsusceptibility. Results were evaluated on the basis of CLSI2010.WHONET5.4and SPSS l8.0were used to analyze the data.Results: During the past3years,835strains of P. aeruginosa wereseparated from all kinds of clinical samples, including165strains ofmultiple drug-resistant P. aeruginosa, which accounted for19.3%. Theresistance rates of the isolated strains of P. aeruginosa to amikacin,ceftazidime, cefoperazone, ciprofloxacin was decreased from17.8%,25.8%,77.9%,28.2%in2009to11.9%,12.8%,25.9%,23.1%in2011,respectively. And its resistance rates to imipenem, beta-lactamase inhibitorscomposite was increased from14.7%,5.3%to11.7%in2009to22.5%,12.2%to14.4%in2011. The detection rate of multiple drug-resistant P.aeruginosa in the ICU was found significantly higher than that in the non-ICU, and the isolated strains of multiple drug-resistant P. aeruginosa,both from ICU and non-ICU, their detection rates were decreased.Compared with the resistance rates of multiple drug-resistant P. aeruginosato ceftazidime, cefepime, cefoperazone in2009, the resistance rates in2011were reduced from61.9%,57.1%,100%to39.0%,51.2%,70.7%,respectively. And the resistance rates to imipenem, beta-lactamaseinhibitors composite in2011rose from33.3%,33.3%to35.7%in2009to58.5%,43.9%to46.3%, respectively.Conclusion: There were more stains of P. aeruginosa separatedfrom ICU than from non-ICU. The resistance rates of P. aeruginosa toimipenem and beta-lactamase inhibitors composite are significantly higherin2011than in2009. The monitoring of antibiotic resistance and themanagement of antibacterials grading system should be strengthened, so asto help guide the rational use of antimicrobials clinically, reduce andcontrol the occurrence of bacterial resistance. |
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