Viral Etiology Associated With The Severity Of Respiratory Infection Among Hospitalized Children In Chongqing Area Of China

Objective:Knowing the viral etiology and the correlation between that and the severity of respiratory infection among hospitalized children in Chongqing area of China.Methods:1745of nasopharyngeal aspirates (NPAs) were prospectively collected between prolonged June2009and May2011from children with acute respiratory infections (ARIs) admitted to Chongqing Children’s Hospital in China. Fourteen respiratory viruses in NPAs were investigated using polymerase chain reactions (PCRs) after having extracted nucleic acids from samples and then synthesized cDNA. According to the severity of disease, we clarified characteristic of severe pneumonia, mild pneumonia and non-pneumonia. All the tests were formed by using the SAS9.13and SPSS17.0. Results:Total1318(75.5%) of1745cases were detected with at least one kind of virus in NPAs. RSV was the most frequently detected virus, with rate of34.2%. Detection of RSV, ADV was associated with severe disease, with adjusted odds ratios (ORs) calculated as1.65and2.36for RSV,3.44and2.94for ADV, when mild and non-pneumonia patients were compared as controls, respectively. HBoV was relevant to lower respiratory infection, with ORs of4.06for severe and2.31for mild compared to non-pneumonia. Co-infection of RSV and other virus was proved not make exacerbation pneumonia.Conclusion:Our study presented a high prevalence of respiratory viral pathogens among hospitalized children with ARIs, demonstrated that RSV and ADV were strongly associated with severe pneumonia. HBoV was relevant to lower respiratory infection. Co-infection of RSV and other virus not contributed to pneumonia severity. These results might guide the vaccines development priority for prevention of respiratory infection in children.