Expression Of VEGF, Her-2and TP In Gastric Carcinoma

Objective:To study the expression of VEGF, Her-2and TP in gastric carcinomaand their clinicopathological sigificance as well as whether there is a correlationamong them in the development of gastric carcinoma.Method:We collected155cases of gastric carcinoma from the patients withcomplete clinical and pathological data who had received surgical treatments fromJanuary to August in2012in Tongji Hospital, Huazhong University of Science andTechnology. The expressions of VEGF, Her-2and TP were detected from the155paraffin-embeded samples by immunohistochemical method and the results wereanalysed by the statistical software SPSS19.0.Results: The expression of VEGF was detected in108of155cases of gastriccarcinoma(69.68%), which showed that VEGF was not significantly correlated withthe gender and age of the patient and the size, differentiation and distant metastasis ofthe tumor (P>0.05)，but was correlated with the depth of tumor invasion, lymph nodemetastasis and clinical TNM stages of gastric carcinoma(P<0.05). The expression ofHer-2was detected in47of155cases of gastric carcinoma(30.32%), which was notsignificantly correlated with the gender and age of the patient,tumor size, depth oftumor invasion, metastasis of lymph node, and distant metastasis and clinical TNMstages of gastric carcinoma(P>0.05), while it was related with the degree ofdifferentiation(P<0.05).The expression of Her-2in well and moderately differentiatedgastric tumor tissue was significantly higher than that in poorly differentiated gastrictumor tissue, and the difference between them was statistically significance. Theexpression of TP was detected in95of155cases of gastric carcinoma (61.29%),which was not correlated with the gender and age of the patient, differentiation anddistant metastasis of the tumor(P>0.05),while it was correlated with the tumor size,depth of tumor invasion, lymph node metastasis and clinical TNM stages of gastric carcinoma(P<0.05).The expression of VEGF was positively correlated with that ofTP(r=0.273，P<0.001), while the expression of Her-2had no significant correlationwith that of VEGF or TP.Conclusion:The expressions of VEGF,Her-2and TP in gastric tumor tissueswere closely related to the incidence and development of gastric tumor. Theexpression of Her-2was selectively correlated with the degree ofdifferentiation,while it had no significant correlation with the expression of VEGF orTP.The results showed that Her-2probably was not directly involved in the regulationof angiogenesis. The expression of VEGF and TP was high in gastric tumor tissue,which had correlation with the depth of tumor invasion, lymph node metastasis andclinical TNM stages of gastric carcinoma(P<0.05), suggesting that VEGF and TP mayplay a significant role in the incidence, development, invasion and metastasis ofgastric carcinoma. The expression of VEGF was positively correlated with that of TP(r=0.273， P<0.001). Both VEGF and TP may play significant roles in tumorangiogenesis of gastric carcinoma, to promote the growth of tumor cells.