| Objective：Through the observation of ShengYangYiweiTang Decoction on chronicatrophic gastritis(CAG) effects of Bcl-2, Bax and MVD in gastric mucosa of model rats withCAGdisease, delay the effectiveness and early use of ShengYangYiweiTang Decoction in thetreatment of CAG.Methods：SPF level100adult Wistar rats were randomly selected10(five male and afemale) as the control group, and the remaining90rats were immunized using ammonia,alcohol, salicylic acid and sodium deoxycholate and other factors to stimulate manufacturingmolding, irregular diet combined with10weeks of continuous replication modeling CAG ratmodel, in the first seven weeks of modeling90rats were randomly divided into model groupintervention, treatment model group, the intervention group, ShengYangYiweiTang low-dose group, ShengYangYiweiTang dose intervention group, ShengYangYiweiTang high dosegroup, ShengYangYiweiTang low-dose treatment group, ShengYangYiweiTang dosetreatment group, ShengYangYiweiTang high-dose treatment group10(5male and afemale), and began the intervention group were given a low dose, middle dose group,low-dose rat high dose group, middle dose and high dose ShengYangYiweiTang interventionfour weeks, and the use of sucralfate to the intervention group was fed contrast.10thweekend in modeling the two models were randomly selected group of10rats were sacrificedgastric tissue pathology, confirmed successful modeling sacrificed collecting samples,inspection control group, the intervention model group, the intervention group, low-doseintervention group, middle dose group and high-dose rat gastric mucosa intervention group.And then were given low-dose treatment group, middle dose group, low-dose treatment ofrats with high-dose group, middle dose and high dose ShengYangYiweiTang4weeks oftreatment, and treatment model rats were sacrificed the same time period, collecting samples,submission gastric mucosa. Rat gastric mucosa in each experimental group Bcl-2, Baxexpression and MVD change the situation by immunohistochemistry.Results：Compared with the control group, the expression of the intervention modelgroup and treatment group of gastric mucosa in rats with Bcl-2decreased, the increase in Baxexpression, decrease in the number of MVD, both P <0.05. Compared with the intervention model group, low dose group, middle dose group and high dose group increased expression ofBcl-2, decreased Bax expression, increased numbers of MVD, P＜0.05. Compared to thecontrol group and intervention, decrease the expression of Bcl-2increased, Bax expression,medium dose intervention group and high dose group, all P <0.05, low dose group, P>0.05;increased the number of MVD, low dose group, middle dose group and high dose interventiongroup, P＜0.05. Compared with the high dose group, Bcl-2, Bax, MVD expression weredose intervention group P <0.05, P <0.05low dose intervention group. Compared withmiddle dose intervention group, Bcl-2, Bax, MVD expression were low dose group, P>0.05.Compared with model group, Bcl-2treatment, expression of fall and rise, the expressionof Bax, low dose group, middle dose group and high dose treatment group, P＜0.05;increased the number of MVD, middle dose group and high dose treatment group, P＜0.05,low dose treatment group, P>0.05. Compared with the high dose treatment groups, Bcl-2,Bax, MVD expression were dose treatment group, P>0.05, low dosage treatment group P <0.05. Compared with middle dose therapeutic group, Bcl-2, Bax, MVD expression were lowdose treatment group, P>0.05.With low dose intervention group, Bcl-2, Bax, MVD expression were low dosagetreatment group P <0.05. Compared with middle dose intervention group, Bcl-2, Bax, MVDexpression were dose treatment group P <0.05. Compared with the high dose group, Bcl-2,Bax, MVD expression was high dosage treatment group P <0.05.Conclusion：ShengYangYiweiTang on CAG rat model has a better therapeutic effect, andearly use of disease with slow CAG role; ShengYangYiweiTang treatment and delay CAGmodel rats may be related to upregulation of Bcl-2has, downregulate the expression of Baxand promote the formation of gastric MVD. |
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