The Relationship Between Serum Preptin Level And PCOS

Objective: Polycystic ovary syndrome (PCOS) is linked to obesity, impaired glucosetolerance and diabetes. Recently, studies have found that preptin enhances insulin secretionin rats and might play a role in the pathogenesis of diabetes and PCOS in humans. Thepurpose of this study was to evaluate the relationship between PCOS, glucose tolerancestatus, and serum preptin level.Methods: This prospective study was conducted in the HuaZhong University of Scienceand Technology； Tongji Medical College affiliated Tongji hospital, Center forReproductive Medicine from October2010to August2011. Anthropometric parameters(age、body mass index、waist-hip ratio), sex hormone concentrations(follicle-stimulatinghormone、luteinizing hormone、total testosterone), blood pressure(systolic blood pressure、diastolic blood pressure), lipid profiles(triglyceride、 total cholesterol、 high-densitylipoprotein、low-density lipoprotein), fasting glucose levels, fasting serum insulin levels,2-h blood oral glucose tolerance test, glycosylated hemoglobin, homeostasis modelassessment-insulin resistance index, and serum preptin of the samples were analyzed.Results: Sixty-three PCOS patients, including33women with normal glucose tolerance(NGT) and30women with impaired glucose tolerance (IGT), and63patients withoutPCOS, including35women with NGT and28women with IGT were recruited in this study.Irrespective of PCOS status, patients with IGT had higher serum preptin levels comparedwith patients with NGT.(In PCOS patients,522.1±135.1pg/ml versus413.7±106.6pg/ml,P<0.01; in non-PCOS patients,466.4±121.1pg/ml versus406.1±79.9pg/ml, P<0.01). Preptin levels in PCOS patients were higher compared with patients without PCOS, but thedifference was not significant.(465.3±131.8pg/ml versus432.9±103.9pg/ml, P>0.05).Fasting serum preptin levels correlated positively with TG (r=0.183, P<0.05),SBP (r=0.200, P<0.05), DBP(r=0.300, P<0.001), FBG(r=0.416, P<0.01),2hOGTT(r=0.286,P<0.01), and HOMA-IR (r=0.178, P<0.05), unrelated with the BMI, WHR, FIns in simpleregression analysis of the pooled data. FBG、DBP and HbA1c were independently relatedwith fasting serum preptin levels, the equation was: Y=-359.665+59.906XFBG+3.415XDBP+37.776XHbA1c. While in multiple stepwise regression analysis, preptin levels wereindependently related with glucose tolerance, but not with PCOS.Conclusion: For patients with and without PCOS, women with IGT had higher serumpreptin levels compared with women with NGT. Preptin levels are related with glucosetolerance status, but not with PCOS status. The changes of fasting serum preptin levelsmaybe associate with glucose and lipid metabolism disorder in PCOS, and it maycontribute partially to pathogenesis of insulin resistance.