| Objective:To investigate and compare the24-hour intraocular pressure, blood pressure and ocularperfusion pressure of primary open-angle glaucoma group and normal control group.Methods:We measured intraocular pressure, blood pressure every2-hour in57POAG patientsand13healthy individuals è all measurements started at8:00until the next6:00. Meanocular per fusion pressure valued, systolic (SOPP) and diastolic (DOPP) ocularperfusion pressure values can be calculated by the formula.Results:There was no differences between the age, gender of the two groups. The IOP wassignificantly higher in the POAG group (p<0.05). The peak value of IOP in POAGgroup appeared in6Am, the valley value appeared in2Pm, however, the peak value of IOPin normal control group appeared in2Am, the valley value appeared in8Pm. Therewas no difference in SBP, DBP, circadian SBP, nocturnal SBP between the two groups(p>0.05); but the variation of circadian SBP and nocturnal SBP was significant (p<0.05). Thedifference of circadian MOPP (exclude the8Am and8Pm’ values) between the two groups wassignificant (p<0.05). The peak value of MOPP in POAG group appeared in6Pm, the valley valueappeared in2Am and4Am; in the normal control group, the peak value appeared in6Pm, thevalley value appeared in0Am and2Am. The variation of circadian and nocturnal MOPPwas significantly higher in POAG group than those in normal control group(p<0.05).Conclusion:The variation of circadian IOP and BP was significant in POAG, additionally, the MOPP reduction and variation of circadian MOPP fluctuation can be observed. It wouldrevealed that the OPP reflected the vascular status at the optic disc, and the reduction ofOPP may be one of the risk factors of the development in POAG. |
