Effects Of High-frequency Oscillatory Ventilation On Oxygenation And Lung Injury Biomarkers In Acute Respiratory Distress Syndrome Piglets

Objective Compare with conventional mechanical ventilation, to explore the effects ofhigh-frequency oscillatory ventilation on oxygenation and assess lung injury on circulatingserum clara cell secretion protein (CC16), soluble intercellular adhesion molecule-1(sICAM-1) and high mobility groupbox-1(HMGB-1) levels in acute respiratory distresssyndrome piglets.Methods12anesthetized piglets were randomly divided into the CMV group and HFOVgroup. a thermo dilution femoral artery catheter and a CVP catheter was respectively insertedinto the femoral artery and the right internal jugular vein. ARDS was induced by repeatedlung lavages. The arterial and venous blood gas of piglets were recorded before lunglavage(T0), after that(T1),0.5h(T2),1h(T3),2h(T4) and4h(T5) after mechanicalventilation.CC16, sICAM-1and HMGB-1were detected at T0, T1and T5.Results After lung lavages than before, PaO2, oxygenation index and DO2decreased,PaCO2、 Qs/Qt and VO2increased, they all showed a significantly statisticaldifference(P<0.05). After mechanical ventilation of the two groups, PaO2and oxygenationindex increased obviously(P<0.05), the improvement of oxygenation was more significant inHFOV group(P<0.05).DO2elevated and Qs/Qt dropped, showed a significantly statistical difference (P<0.05), but there were not different between the two groups. CC16and sICAM-1had dropped mildly(P>0.05). HMGB-1improved at the T5point (P<0.05), we detected nodifferences between the two groups.Conclusion Compared with CMV, HFOV could improve hypoxemia more significantlyand quickly. We detected no differences between HFOV and CMV on ventilator-induced lunginjury, HFOV didn’t aggravate lung injury and inflammatory reaction.