Trial Of The Influence Of Oral Antibiotics On Postoperative Intestinal Flora Recovery

Objective:The study investigated the influence of bowel preparation methods on clinical recovery, using Real-time PCR in patients undergoing colonic cancer resection.Methods:Fifty-eight patients were randomized into Oral antibiotics group(32) and no Oral antibiotics group(26), The feces collected indifferent phases were quantified by Real-time PCR to analyze bacterial amounts.The data of patients in eath group were collected and statistically analyzed,for instance,incidence of anastomotic fistula、 wound infection and lacunar infection, body temperature,count of white blood cell.Results:Levels of Escherichia coli of last bowel movement in hospital was significantly higher,in the no Oral antibiotics group than Oral antibiotics group(p=0.019);The levels of Enterococcus, Bifidobacterium and Lactobacillus were similar between the two groups.(p=0.531、0.638�'�0.106).The incident of anastomotic fistula、lacunar infection and count of white blood cell was significantly higher, in the Oral antibiotics group than Oral antibiotics group.But the incident of wound infection was lower in the Oral antibiotics group than Oral antibiotics group. The incident of pyrexia were similar between the two groups(p=0.374).Conclusion:Although oral antibiotics can reduce SSI, but caused an imbalance in the bowel microflora and flora translocation, increased the other parts of the infection rate, especially lung infection, and SSI can reduce by strengthening the intraoperative incision protection measures,so it does not advocate that colorectal cancer patients with oral antibiotics before operation.