| BackgroundsPulmonary tuberculosis caused by Mycobacterium tuberculosis pulmonary infection, the disease is the main form of communication between people with respiratory. In recent years, the global tuberculosis a stirring among the dry bones, morbidity worldwide and were picked up momentum, especially in developing countries, tuberculosis is still one of the main threats to public health. The tuberculosis epidemic situation of China in the global is a high incidence area, is one of the prevention and control infectious disease. Since the1950s, our country general epidemic situation of tuberculosis has declined, but because population is numerous, each region to control the epidemic is not balanced, known as" white plague" tuberculosis is now revived again, mainly concentrated in the migrant workers live in dense, large labor intensity, poor nutrition, decreased body resistance in the crowd. Haining as the first economic strong county (city) of northern Zhejiang, especially since the late1990s, along with the continuous influx of new residents, tuberculosis incidence rate showed an upward trend. Tuberculosis remains an important current public health problem,is one of the top ten causes of death, should cause us serious concern.Trace elements directly involved in the metabolism of the human body, they are in various forms in vivo keep dynamic balance, deficiency or excess can lead to the change of the normal physiological activities and biochemical processes, caused by abnormalities of cell metabolism, growth and reproduction disorders, cell mutation, cancer achieve a certain degree. Therefore, maintaining the human body organ trace element balance and relatively stable, is of great significance to human health and disease rehabilitation. The trace element content determination of patienes and the healthy human body, can obain many important information of trace elements and disease, determination of trace elements in study of pulmonary tuberculosis in the occurrence and development, reveals the mechanism and prevention of tuberculosis has very important significance.Materials&MethodsThis study required research object serum and data provide by the Haining Center for Disease Control and prevention, include:①Determination the serum content of calcium, magnesium, iron, copper, zinc five kinds of trace elements in tuberculosis patients and normal group, calculation of the mean and standard deviation about copper zinc ratio and trace element indicators, analysis of the difference between tuberculosis patients and normal groups of various trace elements, to explore the relationship between trace elements and tuberculosi;(2)Pulmonary tuberculosis patients and normal people groups according to gender, age factors subgroup was compared, removal of interference factors,analysis of gender, age, whether tuberculosis related factors.Results1Calcium determination resultsThe control group calcium content in the range of77-147mg/L, the mean value of106.28±14.58mg/L; the experimental group calcium content in the range of41-151mg/L, the mean value of102.72±16.77mg/L. Calcium content and age, gender was irrelevant, the experimental group and the control group of calcium determination was no significant difference (P>0.05). 2Magnesium determination resultsMagnesium content in the range of15.7-25.1mg/L in control group, the mean value of19.46±2.31mg/L; the experimental group magnesium content range of12.3-25.1mg/L, the mean value of18.75±2.71mg/L. Magnesium content and age, gender was irrelevant, the experimental group and the control group of magnesium determination was no significant difference (P>0.05).3Iron determination resultsThe control group of iron content in the range of0.51-5.27mg/L, the mean value of1.59±0.77mg/L; the experimental group iron content range of0.44-6.46mg/L, the mean value of1.39±0.96mg/L. Iron element content and age, gender was irrelevant, the experimental group and the control group iron determination value had significant difference (P<0.05), and the experimental group iron determination value was lower than the control group.4Copper determination resultsCopper content in the range of0.46-1.93mg/L in control group, the mean value of1.06±0.31mg/L; the experimental group copper content range of0.76-4.31mg/L, the mean value of1.68±0.64mg/L. Copper content and age, gender was irrelevant, the experimental group and the control group determination of copper values have significant difference (P<0.05), and the experimental group determination of copper values were higher than the control group.5Zinc determination resultsZinc content in the range of0.642-2.504mg/L in control group, the mean value of0.965±0.246mg/L; the experimental group zinc content range of0.399-1.12mg/L, the mean value of0.704±0.132mg/L. The content of zinc and the age, gender was irrelevant, the experimental group and the control group zinc determination value had significant difference (P<0.05), and the experimental group zinc determination value was lower than the control group. 6Copper zinc ratio determination resultsThe control group of copper zinc ratio in the range of0.42-2.74, average1.14±0.42; the experimental group copper zinc ratio in the range of0.97-7.37, average2.51±1.20. Copper zinc ratio and age, gender was irrelevant, the experimental group and the control group of copper zinc ratio determination value had significant difference (P<0.05), and copper zinc ratio in experimental group was higher than that of control group.7Aluminum determination resultsThe control group of aluminium content range of0.14-2.13mg/L, the average value of0.46±0.48mg/L; disease group aluminum content range0.20-8.61mg/L, with an average value of0.71±0.99mg/L. Aluminum content has nothing to do with age, sex, the control group and the patient group aluminium determination values were significantly different (P<0.05), and the prevalence of aluminum group was higher than that of control group.8Selenium determination resultsThe control group selenium content in the range0.065-0.170mg/L, with an average value of0.121±0.023mg/L; disease group selenium content range0.065-0.270mg/L, with an average value of0.119±0.028mg/L. Selenium content was independent of age, gender, the control group had no significant difference in patient group selenium determination value difference (P>0.05).9Manganese determination resultsThe control group of manganese content range of0.00645-0.00915mg/L, the average value of0.00765±0.00057mg/L; disease group manganese content range0.00500-0.01205mg/L, with an average value of0.00698±0.00134mg/L. Manganese content has nothing to do with age, sex, the control group and the patient group manganese determination values were significantly different (P<0.05), and the prevalence of manganese group than in the control group. 10Arsenic determination resultsThe control group of arsenic content range0.00300-0.01315mg/L, with an average value of0.00719±0.00193mg/L;0.00460-0.02150mg/L disease group arsenic content range, with an average value of0.00820±0.00293mg/L. Arsenic content has nothing to do with age, sex, the control group had no significant difference in patient group arsenic determination value difference (P>0.05).11Cadmium determination resultsThe control group of cadmium content range of0.00620-0.00685mg/L, the average value of0.00647±0.00015mg/L; disease group cadmium content range0.00500-0.00875mg/L, with an average value of0.00655±0.00041mg/L. Cadmium content has nothing to do with age, sex, the control group had no significant difference in patient group cadmium determination value difference (P>0.05).Conclusion1Comparison serum trace elements with tuberculosis patients and normal human In sera of pulmonary tuberculosis patients, Ca,Mg,Se,As,Cd levels in pulmonary tuberculosis patients and normal control group had no significant difference (P>0.05), Fe, Cu, Zn,Al,Mn levels in patients with pulmonary tuberculosis and normal group had significant difference, among pulmonary tuberculosis patients, Cu and Al content was higher than those in normal controls, Fe,Zn and Mn were significantly lower than that of normal group.2Relationship of serum trace elements with gender, age Pulmonary tuberculosis patients and normal people group in serum of calcium, magnesium,iron,copper and zinc five kinds of trace elements in gender, age and other factors associated with no relevance. Gender, age did not influence the content of trace elements in serum. |
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