Correlation Of Plasma Osteopontin Levels With Formation Of Coronary Collateral

ObjectiveInvestigate the correlation between plasma osteopontin levels and the formation of coronary collateral circulation.Analysis the factors influence the coronary collateral circulation formation. Search for the potential treating target site of coronary heart diseases.MethodsSelect176patients who are admitted to the Second Affiliated Hospital of Zhejiang Univerisity and collect the general datas and laboratory examination outcomes. Detect the plasma OPN levels of the blood sample before cardioangiography with Elisa methods.Post cardioangiography,2cardiology department doctors evaluate the stenosis condition of coronary arteries and Rentrop Scores base on the condition of coronary collateral circulation.Collate and analyze the data with the software of SPSS17.0,and estimate the correlation between plasma OPN levels and Rentrop Scores. ResultsThere are no significant differences between the plasma osteopontin level of the control group and the weak collateral circulation group (P>0.05),however the group of redundant collateral circulation have higher plasma OPN level than these two groups (P<0.01).This may indicate that low plasma OPN will not support the formation of effective collateral circulation,and those patients who have higer Rentrop Scores may also have a higher osteopontin plasma level.And the plasma OPN is an independent risk factor beside the age,diabetes,hypertension,BMI,family history,drinking, blood fat, serum creatinine and blood urea nitrogen.ConclusionThe plasma OPN levels collelate with coronary collateral circulation,and it is an independent risk factor beside the factors of age,diabetes,hypertension,BMI,family history,drinking, blood fat, serum creatinine and blood urea nitrogen.