Epidemiology Of AKI In Hospitalized Patients

Objective: This study’s objective was to determine the incidence and mortality rate of acute kidney injury (AKI) among hospitalized adult patients in a tertiary metropolitan hospital of China, and to evaluate the impact of AKI on in-hospital mortality.Methods:Retrospective analysis the characteristics of concomitant and underlying diseases, sex distribution, age and distribution of severe AKI patients who were admitted to The First Affiliated Hospital, Zhejiang university. The presence and severity of AKI were assessed using absolute and relative increases from baseline to peak serum creatinine concentration during hospitalization. AKI was defined as a relative50%increase or an absolute increment of0.3mg/dl (26.5umol/1) in serum creatinine. Make a mutable analysis about the relationship of these factors with the outcome of AKI patients.Results:In the3725AKI patients, there are2513males and1212females. In this sample,1996cases had Basis cardiovascular diseases,792patients had metabolic disorders and743cases had chronic kidney disease. Patients of AKIN stage1,2, and3are respectively2,158cases,811cases and756cases. The AKI patients the mortality rate was12.7%, and with the AKIN stage progress to improve (OR=2.461,95%confidence interval,2.190-2.765). The common causes of AKI are infection, important surgery, urinary tract obstruction, hypovolemia and heart stroke. Among these, AKIN stage (P<0.001), RRT (P<0.001), the basis of CKD (P<0.001), hypertension (P=0.001), sepsis(P<0.001) are independent risk factors for the death of AKI patients. Conclusion:AKI is prevalent in the Chinese hospitalized patients. A slight elevation of serum creatinine is associated with significantly increased mortality. The patients who are more serious renal function level, RRT, had CKD, hypertension before, sepsis are independent risk factors for the renal function recovery rate.