The Clinical Effects Of Itopride Hydrochloride In Treating Patients With Functional Dyspepsia

Objeetive: Funetional dysPepsia（FD） is a common clinical disorder of digestivesystem and refraetory disease.Many drugs are used in the clinical treatment of FD.The research confirmed that Itopride hydrochloride and domperidone have certainfunction in promoting gastrointestinal dynamic. This research is intended toinvestigate the clinical therapeutic effects and safety of Itopride hydrochloride intreating patients with functional dyspepsia and provide the new basis for the clinicaltreatment of functional dyspepsia.Methods: A total of120patients diagnosed as having functional dyspepsia throughRome Ⅲ standard at1st Affiliated Hospital of Shihezi University of digestive systemdepartment from January2012to November2012were randomized into treatmentgroup. Thease patients are divided into the control group and treatment grouprandomly. The treatment group was treated with Itopride hydrochloride and controlgroup was treated with Domperidone） for four weeks. The changes in FD symptomssuch as upper abdominal discomfort，abdominal pain，upper abdominal burningsensation，on early enough，acid reflux，nausea，and other symptoms were recordedbefore and after treatment. Grades the symptom and calculate the statistic index ofcurative effect and clinical curative effect.Analyse and compare the related indexes ofthe treatment.Results: The total effective population after treatment in the treatment group andcontrol group respectively is55and47， And The obvious curative effect populationrespectively is22and17， The effective population respectively is33and30， theinvalid population respectively is5and13.The Significant rate respectively is28.3%and36.7%.Compared to total significant rate， there was no statisticallysignificant difference between the two groups. The total effective rate respectively is91.67%and78.3%， significantly higher than the control group， the difference of thetwo groups is statistically significant.There are no adverse drug reactions during andafter treatment in the two groups.Conclusion: Both itopride hydrochloride and domperidone have good clinical curativeeffect in the clinical treatment of FD， and itopride hydrochloride is a new safetyefficacious drug for treating functional dyspepsia．It is popularized in the treatment ofFD patients for significant clinical effect and lower recurrence rate.