Treating Functional Dyspepsia With Jiaolong Capsules Combined With Domperidone

ObjectiveFunctional dyspepsia (FD) is a common clinical disorder of digestive system and refractory disease. The purper of this subject isto observe the curative effect of Jiaolong Capsules combined with Domperidone on FD with stagnant heat of liver and stomach and its effects on gastric emptying.It is intend to provide innovative new drugs of clinical treatment for the disease.MethodsReference to traditional Chinese medicine,and Western medicine diagnostic criteria, FD patients were randomly divided into three groups:patients only treated with Jiaolong Capsules(Group A), patients treated with Domperidone (Group B),and patients treated with Jiaolong Capsules combined with Domperidone(Group C).Each group had 30 cases.All patients were treated for two wceks.The changes in FD symptoms such as upper abdominal fullness,stomach cauterization,dry and bitter taste were recorded before and after treatment.Efficacy index was calculated.Using 13C-octanoic acid breath test the emptying function of stomach was determined.Results1 After treatment, upper abdominal fullness,stomach cauterization and other symptom scores of three groups decreased than before,and after treatment than before treatment was significantly(P<0.05).2 Three groups of symptoms total score after treatment than before treatment were decreased. And after treatment than before treatment was significantly (P<0.05). Comparison between the 3 groups, group C improvement is better than group A, B (P<0.05), the difference between group A and group B was not significant (P> 0.05).3 After treatment, the total effective number of three groups are 22,21,28. And the total effective rate was 73.3%,70%and 93.3%. Compared to the total numer of valid cases, C group was better than group A, B (P<0.05).The difference between group A and B was not significant (P> 0.05).4 Gastric emptying test showed that after treatment, gastric emptying time of three groups were significantly improved compared with before treatment (P<0.05). In the three groups, the difference was not significant (P> 0.05).5 During treatment, two patients had mild abdominal pain in group A, and 4 patients had mild abdominal pain and diarrhea in group C(2 times/day). These symptoms disappeared afterthe treatment. In the follow-up process, only one patie-nt in group B occurred early satiety symptoms.The other group had no recurrence.Conclusion1 Combined therapy of Jiaolong Capsules and Domperidone can significantly improve general efficacy in patients of functional dyspepsia with stagnant heat of liver and stomach syndrome. Patients with upper abdominal fullness,stomach cauterization,dry and bitter taste has obvious improvement.2 Combined therapy of Jiaolong Capsules and Domperidone in patients of functional dyspepsia with stagnant heat of liver and stomach syndrome can accelerate the gastric emptying,.They have a clear role in promoting gastric motility.3 Combined therapy of Jiaolong Capsules and Domperidone in patients of functional dyspepsia with stagnant heat of liver and stomach syndrome has no adverse reaction. It deserves further study and promotion.