Analysis Of The371Drug-resistance Of Tuberculosis Strings From The Southern Regions Of Xinjiang

Objective: To analyze drug-resistance of tuberculosis from the southern regions ofXinjiang, and provide the evidence for the control and prevention. Methods:Sputumsamples from patients with TB were collected from the southern regions of Xinjiang fromMay2010to May2011. The cultivation, and preliminary identification of MTB weredone. The proportion method was used for testing the strains’ susceptibility to8anti-tuberculosis drugs (isoniazid、rifampicin、streptomycin、ethambuol、capreomycin、kanamycin、amikacin、ofloxacin),and then analysis the results.Results:371strains wereincluded the prevalence of overall resistance among all cases was32.1%,the drug-resistance rate of the new cases was30.3%,and the re-treatment cases was33.2%.Thesequence of the drug resistance was isoniazid>rifampicin>streptomycin> ethambuol>capreomycin>kanamycin>ofloxacin>amikacin.314(84.%) are mycobacterium tuberculosis.5(14.8%)are mycobacterium bovis.2(0.6%)belong nontuberculosis mycobacteria, thereare145in the newly diagnosed patients,drug resistance44,the drug resistance rate is30.3%.there are226in the relapsed patients, drug resistance75,the drug resistance rate is33.2%, higher than the newly diagnosed patients.The single drug resistance is the mostlyin the two groups, The drug resistance rate is17.9%�'�20.4%respectively.21are MDR-TB, drug resistance rate5.7%.8, in the newly diagnosed patients,5.5%,13in the relapsedpatients.5.8%, higher than.the the newly diagnosed patients.There are4resist to HR in themeantime in newly diagnosed patients, in.relapsed patients there have7strains.Conclusions: The status of drug resistance tuberculosis in this area is serious,implement the strategies and strengthen surveillance seriously to prevent against drug-resistance tuberculosis.